Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3-and 5-year follow-up
Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3-and 5-year follow-up
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DOI：
10.1111/jcpe.12894
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发表时间：
2018-06-01
影响因子：
6.7
通讯作者：
Holmlund, Anders
中科院分区：
文献类型：
--
作者：
Isehed, Catrine;Svenson, Bjorn;Holmlund, Anders
目的评估种植体周围炎手术治疗本身或与釉基质衍生物（EMD）相结合后3年和5年的临床和影像学结果。Materials and MethodsAt baseline，29例患者被随机分为手术治疗组和对照组。种植体周围炎手术治疗后1年，25例患者在3年和5年随访时仍符合生存分析的条件。主要结果是种植体损失和骨水平（BL）的变化测量X线片，和次要结果，出血探测，脓和斑块在每个种植体进行了分析，在18和14例患者在3年和5年follows.ResultsAfter排除4例患者谁中止了研究，在3年的随访，13（100%）种植体存活在EMD组，非EMD组12例中10例（83%）。5年随访时，EMD组13个种植体中有11个（85%）存活，非EMD组12个种植体中有9个（75%）存活。在多变量模型中，BL变化和EMD治疗与种植体存活率呈正相关。同样，在单变量analysis.ConclusionsAn探索性分析表明，连续EMD与种植体生存率呈正相关长达5年，但需要更大的研究。
ObjectiveTo assess the clinical and radiographic outcomes 3 and 5years after the surgical treatment of peri-implantitis per se or in combination with an enamel matrix derivative (EMD).Materials and MethodsAt baseline, 29 patients were randomized to surgical treatment with adjunctive EMD or no EMD. One year after the surgical treatment of peri-implantitis, 25 patients remained eligible for survival analyses at the 3- and 5-year follow-up. The primary outcomes were implant loss and bone level (BL) change measured on radiographs, and the secondary outcomes, bleeding on probing, pus and plaque at each implant were analysed in 18 and 14 patients at the 3- and 5-year follow-up, respectively.ResultsAfter exclusion of four patients who discontinued the study, at the 3-year follow-up, 13 (100%) implants survived in the EMD group, and 10 of 12 (83%) in the non-EMD group. At the 5-year follow-up, 11 of 13 (85%) implants in the EMD group and nine of 12 (75%) in the non-EMD group survived. In multivariate modelling, BL changes and EMD treatment were positively associated with implant survival. Similarly, the same trend was seen in univariate analysis.ConclusionsAn exploratory analysis suggests that adjunctive EMD is positively associated with implant survival up to 5 years, but larger studies are needed.