ABNORMALITIES OF NONVISUALLY-GUIDED EYE-MOVEMENTS IN PARKINSONS-DISEASE
ABNORMALITIES OF NONVISUALLY-GUIDED EYE-MOVEMENTS IN PARKINSONS-DISEASE
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DOI：
10.1093/brain/112.6.1573
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发表时间：
1989-12-01
期刊：
影响因子：
14.5
通讯作者：
KENNARD, C
中科院分区：
文献类型：
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作者：
CRAWFORD, TJ;HENDERSON, L;KENNARD, C
对7例原发性帕金森病（PD）患者和一组匹配的正常对照者进行了快速眼动（扫视）检查。使用3个实验范式检查用于引起扫视的指令和刺激条件的效果。与对照组相比，PD患者由新的外周靶点直接引起的眼球运动未受损。然而，在PD组中，对记住的目标位置的扫视是不对称的，并显示出特征性的多步模式。PD损伤不是由靶位置信息丢失引起的，因为他们的最终眼位在所有偏心率下都接近靶。峰值速度，持续时间和潜伏期没有区分PD患者和对照组。这些结果支持这样的观点，即对于不是由视觉目标直接引起的扫视，存在可以与视觉引起的（或“反射性”）扫视的产生中所涉及的结构区分开的神经通路。在PD中，对记住的目标的扫视被选择性地损害，这一发现表明基底神经节中的结构在该替代途径中起关键作用。
Rapid eye movements (saccades) were examined in 7 patients with idiopathic Parkinson''s disease (PD) and a matched group of normal control subjects. The effect of instructional and stimulus conditions used to elicit saccades was examined using 3 experimental paradigms. Eye movements directly elicited by a novel peripheral target were unimpaired in patients with PD as compared with control subjects. Saccades to a remembered target location, however, were dysmetric in the PD group and showed a characteristic multistepping pattern. The PD impairment was not caused by a loss of information on target location since their final eye position was close to the target at all eccentricities. Peak velocity, duration, and latency did not distinguish between PD patients and controls. These results support the view that for saccades which are not directly elicited by a visual target there is a neural pathway that can be distinguished from structures involved in the generation of visually elicited (or ''reflexive'') saccades. The finding that in PD saccades to a remembered target are selectively impaired suggests that structures in the basal ganglia play a crucical role in this alternative pathway.