Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls
Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls
复制标题
DOI：
10.1210/jc.2003-031572
复制
发表时间：
2004-04-01
影响因子：
5.8
通讯作者：
Cummings, DE
中科院分区：
文献类型：
--
作者：
McLaughlin, T;Abbasi, F;Cummings, DE
生长激素释放肽，一种可能在体重调节中起作用的食欲激素，在肥胖状态下减少。由于肥胖与胰岛素抵抗和代偿性高胰岛素血症有关，我们确定这些代谢特征是否与受抑制的ghrelin浓度独立相关。为了研究这一假设，使用稳态血糖浓度，我们确定了20个胰岛素抵抗（IR）和20个胰岛素敏感（IS）的个人谁是同样肥胖。IR组和IS组的平均体重指数分别为32.5+/-0.4和32.0+/-0.4 kg/m2。空腹胰岛素浓度分别为19.5和7.4 μ U/ml（P
Ghrelin, an orexigenic hormone that may play a role in body weight regulation, is reduced in states of obesity. Because obesity is associated with insulin resistance and compensatory hyperinsulinemia, we determined whether these metabolic characteristics were independently associated with suppressed ghrelin concentrations. To investigate this hypothesis, using steady-state plasma glucose concentrations, we identified 20 insulin-resistant (IR) and 20 insulin-sensitive (IS) individuals who were equally obese. The mean body mass indexes were 32.5+/-0.4 and 32.0+/-0.4 kg/m(2) for the IR and IS groups, respectively. Fasting insulin concentrations were 19.5 and 7.4 muU/ml (P