Arachidonic acid metabolism in human and bovine retina.
Arachidonic acid metabolism in human and bovine retina.
复制标题
人和牛视网膜中的花生四烯酸代谢。
DOI：
10.1089/jop.1991.7.135
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Kulkarni,PS
中科院分区：
文献类型：
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作者：
Kulkarni,PS
研究了花生四烯酸(AA)在人和牛视网膜中的代谢。本研究证明人和牛视网膜可由14C-AA合成前列腺素E_2(PG)E_2、F_2α、I_2、D_2和血栓素A_2。该组织还合成了白三烯(LT)B4和12-羟基二十碳四烯酸(12-HETE)。虽然人和牛的视网膜将AA代谢成PGs和LT，但合成这些产物的能力远远低于其他一些物种的眼组织。
Arachidonic acid (AA) metabolism in the human and bovine retina was assessed. This study demonstrates that the human and bovine retina can synthesize prostaglan-din (PG) E2, F2α, I2, D2and thromboxane A2from14C-AA. This tissue also synthesized leukotriene (LT) B4, and 12-hydroxyeicosatetraenoic acid (12-HETE). Although human and bovine retina metabolized AA into PGs and LTs, the ability to synthesize these products was considerably less than some other ocular tissues of various species.