The effect of glucagon-induced gastric relaxation on TLOSR frequency.
The effect of glucagon-induced gastric relaxation on TLOSR frequency.
复制标题
胰高血糖素诱导的胃舒张对 TLOSR 频率的影响。
DOI：
10.1046/j.1365-2982.2003.00386.x
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kahrilas,PJ
中科院分区：
文献类型：
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作者：
Chang,HY;Pandolfino,JE;Shi,G;Boeckxstaens,GE;Joehl,RJ;Kahrilas,PJ
本研究旨在确定胰高血糖素诱导的胃松弛对短暂性食管下括约肌松弛（TLOSRs）频率的影响。8名正常受试者（4名男性，年龄18-52岁）在使用组合式压力计静压装置禁食6小时后进行了研究。记录分为两个1小时的时段：(1)基线期，气压调节器设置为最小扩张压力(MDP) + 2 mmHg;(2)持续胰高血糖素或安慰剂输注，气压调节器设置为MDP + 2 mmHg。患者在两个不同的天进行研究，随机给予胰高血糖素（4.8 μg kg−1次，随后9.6 μg kg−1次输注），另一天给予安慰剂（生理盐水）。测定安慰剂和胰高血糖素输注组食管下括约肌（LOS）压力、TLOSRs频率和气压袋体积。与安慰剂相比，胰高血糖素可引起显著的眼底松弛（P < 0.05），并显著降低基线LEOS压力（P < 0.05）。与安慰剂相比，胰高血糖素输注没有改变TLOSRs的频率。尽管胰高血糖素引起大量近端胃松弛，但并未增加TLOSR频率。这表明，负责触发TLOSRs的相关胃机械受体对被动伸长没有反应。
This study aimed to determine the effect of glucagon‐induced gastric relaxation on the frequency of transient lower oesophageal sphincter relaxations (TLOSRs). Eight normal subjects (four male, age 18–52 y) were studied after a 6‐h fast using a combined manometric barostat assembly. The recording was divided into two 1‐h sessions: (1) a baseline period with the barostat set at minimal distending pressure (MDP) + 2 mmHg and (2) a period with continuous glucagon or placebo infusion with barostat set at MDP + 2 mmHg. Patients were studied on two different days and randomly received glucagon (4.8 μg kg−1bolus followed by 9.6 μg kg−1h−1infusion) on 1 day and placebo (saline) on another. Lower oesophageal sphincter (LOS) pressure, frequency of TLOSRs, and barostat bag volumes were determined for both placebo and glucagon infusion. Glucagon induced significant fundal relaxation compared with placebo (P < 0.05) and significantly decreased baseline LEOS pressure (P < 0.05). The frequency of TLOSRs was not altered by glucagon infusion compared with placebo. Despite causing substantial proximal stomach relaxation, glucagon did not increase TLOSR frequency. This suggests that the relevant gastric mechanoreceptors responsible for triggering TLOSRs do not respond to passive elongation.