Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure
Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure
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DOI：
10.1161/hypertensionaha.121.17441
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发表时间：
2021-10-01
期刊：
影响因子：
8.3
通讯作者：
Cassidy, Aedin
中科院分区：
文献类型：
--
作者：
Jennings, Amy;Koch, Manja;Cassidy, Aedin
我们首次评估了肠道微生物组的组成在多大程度上可以解释习惯性类黄酮和富含类黄酮的食物摄入量与北方德国社区样本（N=904）中收缩压和舒张压（BP）的横截面关联。从16 S核糖体RNA基因测序肠道微生物组组成。较高的总黄酮摄入量，特别是聚合物亚类与较低的收缩压相关（SBP; β T3-T1：-2.9% [95% CI，-5.1至-0.7]，P=0.01和-3.7% [95% CI，-5.4至-1.0]，P=0.01）。在基于食物的分析中，（收缩压，β Q4-Q1：-2.9% [95%CI，-5.2至-0.6]，P=0.01;脉压，-5.5% [95%CI，-9.6至-1.2]，P=0.01）和红酒（收缩压，β Q4-Q1：-2.6% [95%CI，-4.8至-0.3]，P=0.03;脉压，-6.1% [95% CI，-10.1至-2.0]，P
We assessed, for the first time, to what extent the composition of the gut microbiome might explain the cross-sectional association of habitual flavonoid and flavonoid-rich food intake with systolic and diastolic blood pressure (BP) in a community-based sample (N=904) from Northern Germany. Gut microbiome composition was sequenced from 16S ribosomal RNA genes. Higher total flavonoid intakes and specifically the polymer subclass were associated with lower systolic BP (SBP; beta T3-T1: -2.9% [95% CI, -5.1 to -0.7], P=0.01 and -3.7% [95% CI, -5.4 to -1.0], P=0.01). In food-based analyses, a higher intake of berries (SBP, beta Q4-Q1: -2.9% [95% CI, -5.2 to -0.6], P=0.01; pulse pressure, -5.5% [95% CI, -9.6 to -1.2], P=0.01) and red wine (SBP, beta Q4-Q1: -2.6% [95% CI, -4.8 to -0.3], P=0.03; pulse pressure, -6.1% [95% CI, -10.1 to -2.0], P