The 5-HT7 receptor system as a treatment target for mood and anxiety disorders: A systematic review.
The 5-HT7 receptor system as a treatment target for mood and anxiety disorders: A systematic review.
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DOI：
10.1177/02698811231211228
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发表时间：
2023-12
影响因子：
4.1
通讯作者：
Stokes, Paul R. A.
中科院分区：
文献类型：
--
作者：
Gottlieb, Natalie;Li, Tse-Yi;Young, Allan H.;Stokes, Paul R. A.
临床前动物和初步的人类研究表明，5-HT 7拮抗剂具有作为情绪和焦虑障碍的新治疗方法的潜力。在这篇系统性综述中，我们旨在回顾5-HT 7受体系统与情绪和焦虑障碍之间的关系，并探索靶向5-HT 7受体的药物治疗的药理学和治疗潜力。使用Medline、科克伦图书馆、EMBASE、PsycINFO数据库、美国国立卫生研究院网站Clinicaltrials.gov、controlled-trials.com和相关灰色文献检索原始研究文章，然后手工检索纳入文章的参考文献列表。64项研究被纳入综述：52项动物研究和12项人体研究。研究使用了各种临床前范例和问卷来评估情绪的变化，很少有研究检查睡眠或认知。47项临床前5-HT 7调节研究中有44项（44/47）确定了潜在的抗抑郁作用，20/23项研究确定了潜在的抗焦虑作用。在临床研究中，5/7确定了重度抑郁症的潜在抗抑郁作用，1/2确定了广泛性焦虑症的潜在抗焦虑作用，3/3确定了双相情感障碍的潜在抗抑郁作用。虽然有一些证据表明5-HT 7受体系统可能是治疗情绪和焦虑症的潜在靶点，但该综述中包括的许多药物也与其他受体结合。需要进一步的研究，使用特异性结合5-HT 7受体的药物，以进一步检查治疗概念的证据。
Preclinical animal and preliminary human studies indicate that 5-HT7 antagonists have the potential as a new treatment approach for mood and anxiety disorders. In this systematic review, we aimed to review the relationship between the 5-HT7 receptor system and mood and anxiety disorders, and to explore the pharmacology and therapeutic potential of medications that target the 5-HT7 receptor for their treatment. Medline, Cochrane Library, EMBASE, PsycINFO databases, the National Institute of Health website Clinicaltrials.gov, controlled-trials.com, and relevant grey literature were used to search for original research articles, and reference lists of included articles were then hand searched. Sixty-four studies were included in the review: 52 animal studies and 12 human studies. Studies used a variety of preclinical paradigms and questionnaires to assess change in mood, and few studies examined sleep or cognition. Forty-four out of 47 (44/47) preclinical 5-HT7 modulation studies identified potential antidepressant effects and 20/23 studies identified potential anxiolytic effects. In clinical studies, 5/7 identified potential antidepressant effects in major depressive disorder, 1/2 identified potential anxiolytic effects in generalized anxiety disorder, and 3/3 identified potential antidepressant effects in bipolar disorders. While there is some evidence that the 5-HT7 receptor system may be a potential target for treating mood and anxiety disorders, many agents included in the review also bind to other receptors. Further research is needed using drugs that bind specifically to 5-HT7 receptors to examine treatment proof of concept further.
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DOI：
10.1017/s1461145711001027
发表时间：
2012-06
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Alvarez E;Perez V;Dragheim M;Loft H;Artigas F
通讯作者：
Artigas F
影响因子：
2.6
作者：
Baldwin, David S.;Loft, Henrik;Florea, Ioana
通讯作者：
Florea, Ioana
影响因子：
2.7
作者：
Forbes, IT;Douglas, S;Thomas, DR
通讯作者：
Thomas, DR
影响因子：
3.4
作者：
Abbas, Atheir I.;Hedlund, Peter B.;Huang, Xi-Ping;Tran, Thuy B.;Meltzer, Herbert Y.;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
2.7
作者：
Balcer, Olivia M.;Seager, Matthew A.;Witkin, Jeffrey M.
通讯作者：
Witkin, Jeffrey M.