Chromatographic methods for the simultaneous determination of mycotoxins and their conjugates in cereals
Chromatographic methods for the simultaneous determination of mycotoxins and their conjugates in cereals
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DOI：
10.1016/j.ijfoodmicro.2007.07.022
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发表时间：
2007-10-20
影响因子：
5.4
通讯作者：
Schuhmacher, Rainer
中科院分区：
文献类型：
--
作者：
Berthiller, Franz;Sulyok, Michael;Schuhmacher, Rainer
目前已知的真菌毒素约有300-400种。在某种程度上，这些化合物表现出非常不同的物理化学性质，这导致了对各种基质中的单一毒素或某些类别的真菌毒素的大量分析方法。由于共同发生的毒素的协同作用，已经努力同时检测和量化几种真菌毒素。本文讨论了几种已发表的LC-MS/MS多重真菌毒素检测方法，并介绍了一种新的方法，该方法可以同时检测和定量谷物中90种主要真菌毒素和其他次生真菌代谢产物。此外，已知的真菌毒素的植物衍生代谢物，如玉米赤霉烯酮-4-葡萄糖苷或脱氧雪腐镰刀菌醇-3-葡萄糖苷也包括在该方法中。并简要讨论了真菌毒素偶联物的意义。(C) 2007 Elsevier B.V.版权所有
About 300-400 mycotoxins are known today. To some extent these compounds show very different physicochemical properties, which led to a vast quantity of analytical methods for single toxins or certain classes of mycotoxins in a variety of matrices. Due to synergistic effects of co-occuring toxins, endeavors have been made to simultaneously detect and quantify several classes of mycotoxins. This paper discusses several of the published LC-MS/MS multi-mycotoxin-methods and also introduces a new method, which allows the concurrent detection and quantification of 90 major mycotoxins and other secondary fungal metabolites in cereals. Even more, known plant derived metabolites of mycotoxins, like zearalenone-4-glucoside or deoxynivalenol-3-glucoside are included in this method. The significance of mycotoxin conjugates is briefly discussed as well. (C) 2007 Elsevier B.V. All rights reserved.