Nickel-Catalyzed Borylation of Aryl- and Benzyltrimethylammonium Salts via C-N Bond Cleavage
Nickel-Catalyzed Borylation of Aryl- and Benzyltrimethylammonium Salts via C-N Bond Cleavage
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通过 C-N 键断裂镍催化芳基三甲基铵盐和苄基三甲基铵盐的硼化
DOI：
10.1021/acs.joc.5b02557
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发表时间：
2016-01-01
影响因子：
3.6
通讯作者：
Shi, Zhuangzhi
中科院分区：
文献类型：
--
作者：
Hu, Jiefeng;Sun, Heqing;Shi, Zhuangzhi
通过建立一个温和的ni催化体系，建立了sp(2)和sp(3) C-N键直接硼化的方法。这种高效的C-N键硼化裂解的关键取决于镍催化剂Ni(COD)(2)的适当选择，ICy中心点HCl作为配体，以及2-乙氧基乙醇作为助溶剂的使用。该转化具有良好的官能团相容性，可作为克级合成和后期C-N硼化配合物的有力合成工具。
By developing a mild Ni-catalyzed system, a method for direct borylation of sp(2) and sp(3) C-N bonds has been established. The key to this hightly efficient C-N bond borylative cleavage depends on the appropriate choice of the nickel catalyst Ni(COD)(2), ICy center dot HCl as a ligand, and the use of 2-ethoxyethanol as the cosolvent. This transformation shows good functional group compatibility and can serve as powerful synthetic tool for gram-scale synthesis and late-stage C-N borylation of complex compounds.