PILI AS A MEDIATOR OF ATTACHMENT OF GONOCOCCI TO HUMAN ERYTHROCYTES
PILI AS A MEDIATOR OF ATTACHMENT OF GONOCOCCI TO HUMAN ERYTHROCYTES
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DOI：
10.1128/iai.13.5.1483-1489.1976
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发表时间：
1976-01-01
影响因子：
3.1
通讯作者：
PEARCE, WA
中科院分区：
文献类型：
--
作者：
BUCHANAN, TM;PEARCE, WA
Isolated pure gonococcal pili were capable of producing direct agglutination of human erythrocytes. Four different strains of gonococci were compared, and hemagglutination was produced by isolated pili or piliated gonococci but not by nonpiliated gonococci of each strain. Pili from each of the 4 strains were antigenically distinguishable using [rabbit] antisera specific for pili to agglutinate piliated gonococci, form precipitin lines in Ouchterlony immunodiffusion or inhibit hemagglutination caused by purified pili or piliated gonococci. These tests also demonstrate some shared antigenicity among pili. Shared antigens among the 4 pili types were quantitated at .ltoreq. 2.5% by radioimmunoassay. Inhibition of hemagglutination was most marked with [rabbit] antiserum to the homologous pili type. Inhibition of hemagglutination by antiserum to heterologous pili suggested that shared antigens on pili from B and 2686 strains of gonococci are located near the erythrocyte attachment moiety of B strain pili and removed from the attachment moiety of 2686 strain pili. Antigenic heterogeneity of pili may prove an important factor in any efforts to use pili as a vaccine for [human] gonorrhea.
