MECHANISMS OF EPILEPTOGENESIS IN PHOTOSENSITIVE EPILEPSY IMPLIED BY THE EFFECTS OF MOVING PATTERNS
MECHANISMS OF EPILEPTOGENESIS IN PHOTOSENSITIVE EPILEPSY IMPLIED BY THE EFFECTS OF MOVING PATTERNS
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DOI：
10.1016/0013-4694(85)91065-x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
WILKINS, AJ
中科院分区：
文献类型：
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作者：
BINNIE, CD;FINDLAY, J;WILKINS, AJ
癫痫样脑电图放电的模式触发可能取决于视觉皮层内的兴奋强度。研究了刺激对神经元活动同步的作用。在10个模式敏感的受试者中，比较了以下模式的影响：静态光栅，在与线正交的方向上振荡的光栅（应该同步方向敏感的皮质单元的活动）和以相同角速度漂移的光栅（应该产生很少或没有同步，因为等高线进入和离开单个神经元的重叠接受野是异步的）。振荡光栅的致痫性最强，而漂移光栅的致痫性最小。在另外2名受试者中，振荡和相位反转模式比漂移光栅更容易引起癫痫。尽管存在其他解释，但这些发现符合假设的预测，即刺激使单个皮质神经元同步有助于光敏受试者的癫痫发生。
The triggering of epileptiform EEG discharges by pattern may depend on the intensity of excitation within the visual cortex. The role of the synchronization of neuronal activity by the stimulus was investigated. In 10 pattern-sensitive subjects the effects of the following patterns have been compared: static gratings, gratings oscillating in a direction orthogonal to the lines (which should synchronize activity in direction-sensitive cortical units) and gratings drifting at the same angular velocity (which should produce little or no synchronization, because the contours enter and leave the overlapping receptive fields of individual neurons asynchronously). The oscillating gratings were most, and the drifting least, epileptogenic. In 2 further subjects oscillating and phase-reversing patterns were more epileptogenic than drifting gratings. Although open to alternative explanations, the findings conform with predictions from the hypothesis that synchronization of individual cortical neurons by the stimulus contributes to epileptogenesis in photosensitive subjects.