Adipose tissue in control of metabolism.
Adipose tissue in control of metabolism.
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DOI：
10.1530/joe-16-0211
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Liu M
中科院分区：
文献类型：
--
作者：
Luo L;Liu M
脂肪组织通过其在器官和全身水平上的微妙功能，在调节全身能量和葡萄糖稳态中发挥着核心作用。一方面，脂肪组织以脂质的形式储存能量，并控制脂质在体内的动员和分布。另一方面，脂肪组织充当内分泌器官，并产生许多生物活性因子，例如与其他器官通讯并调节一系列代谢途径的脂肪因子。此外，棕色和米色脂肪组织通过以热量形式耗散能量来燃烧脂质以维持体温，被认为是对抗肥胖的新方法。因此，脂肪组织功能障碍在肥胖及其相关疾病（例如胰岛素抵抗、心血管疾病、糖尿病、抑郁症和癌症）的发展中起着重要作用。在这篇综述中，我们将总结脂肪组织在代谢控制方面的最新发现，重点关注其内分泌和产热功能。
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity. Therefore, adipose tissue dysfunction plays a prominent role in the development of obesity and its related disorders such as insulin resistance, cardiovascular disease, diabetes, depression and cancer. In this review, we will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.