Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance
Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance
复制标题
DOI：
10.1097/qad.0b013e3280114a29
复制
发表时间：
2007-01-11
期刊：
影响因子：
3.8
通讯作者：
Hecht, Frederick M.
中科院分区：
文献类型：
--
作者：
Colfax, Grant Nash;Vittinghoff, Eric;Hecht, Frederick M.
我们确定了甲基苯丙胺的使用是否与最近感染艾滋病毒的男性发生性关系的男性队列中原发性艾滋病毒耐药性的患病率增加有关。在多变量分析中，我们发现频繁使用甲基苯丙胺与原发性非核苷类逆转录酶抑制剂耐药密切相关，但与蛋白酶抑制剂或核苷类逆转录酶抑制剂耐药无关。我们推测，这种关联可能是由源合作伙伴之间的甲基苯丙胺相关的治疗中断引起的。
We determined whether methamphetamine use is associated with the increased prevalence of primary HIV drug resistance among a cohort of men who have sex with men recently infected with HIV. In multivariate analysis, we found that frequent methamphetamine use was strongly associated with primary non-nucleoside reverse transcriptase inhibitor resistance, but not with protease inhibitor or nucleoside reverse transcriptase inhibitor resistance. We postulate that this association may be caused by methamphetamine-associated treatment interruptions among source partners.