Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes.
Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes.
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DOI：
10.1016/j.humimm.2016.04.011
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发表时间：
2016-06
期刊：
影响因子：
2.7
通讯作者：
Kang I
中科院分区：
文献类型：
--
作者：
Lee N;Shin MS;Kang Y;Park K;Maeda T;Nishioka H;Fujii H;Kang I
单核细胞产生高水平的炎性细胞因子，包括IL-6和TNF-α，其参与自身免疫、炎性疾病、心血管疾病和肥胖。靶向IL-6和TNF-α的疗法已用于治疗慢性炎性疾病。低聚酚是荔枝果实衍生的低分子形式的多酚混合物，通常是儿茶素型单体和原花青素的低聚物，其通过低聚过程产生。尽管先前的研究报道了Oligonol的抗炎特性，但尚不清楚Oligonol是否以及如何抑制人单核细胞中IL-6和TNF-α的产生。我们的研究结果表明，通过流式细胞术和ELISA测定，Oligonol（25 μg/ml）可降低人原代单核细胞产生IL-6和TNF-α。这种抗细胞因子作用可能是通过抑制NF-κ B活化而介导的，而不诱导细胞死亡。我们的研究结果提高了探索Oligonol在控制人类炎症条件，特别是与单核细胞相关的炎症条件中的益处的可能性。
Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecular form of polyphenol mixture, typically catechin-type monomers and oligomers of proanthocyanidins, which are produced by an oligomerization process. Although previous studies reported anti-inflammatory properties of Oligonol, it is unknown whether and how Oligonol suppresses IL-6 and TNF-α production in human monocytes. The results of our study demonstrate that Oligonol (25 μg/ml) decreases the production of IL-6 and TNF-α from human primary monocytes as measured by flow cytometry and ELISA. Such an anti-cytokine effect was likely mediated by the suppression of NF-kB activation without inducing cell death. Our findings raise the possibility of exploring the benefits of Oligonol in controlling inflammatory conditions, especially those associated with monocytes, in humans.