Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar rats
Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar rats
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DOI：
10.1590/s0103-64402010000300003
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发表时间：
2010-01-01
影响因子：
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通讯作者：
Lima, Vilma
中科院分区：
文献类型：
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作者：
Goes, Paula;Lima, Ana Patrícia Souza;Lima, Vilma
本研究旨在探讨阿托伐他汀（ATV）对大鼠牙槽骨丢失的影响。通过在总共24只雄性Wistar大鼠（± 200 g）的左上第二磨牙周围结扎来诱导牙周炎。每组6只动物在11天内通过经口灌胃接受生理盐水或ATV（1、3和9 mg/kg）。此后，处死动物，取出其上颌骨，去死皮，通过迪戈拉系统进行X线照相，然后染色，使用数码相机拍照。通过ANOVA和Bonferroni检验在5%显著性水平下对数据进行统计学分析，并以平均值± SEM表示。与生理盐水（79.8 ± 6.2灰色调）相比，ATV（9 mg/kg）导致灰色调变化显著增加超过48%（118.3 ± 12.0灰色调），表明放射学密度更高。这些数据得到了肉眼观察结果的证实，ATV（9 mg/kg）使牙槽骨丢失减少了47%以上（p
The purpose of this study was to evaluate the effect of Atorvastatin (ATV) on alveolar bone loss induced in rats. Periodontitis was induced by ligature placement around the upper second left molar in a total of 24 male Wistar rats (± 200 g). Groups of 6 animals received via oral gavage either saline or ATV (1, 3 and 9 mg/kg) during 11 days. After this time, the animals were sacrificed and their maxillae were removed, defleshed, radiographed by Digora System, and latter stained to be photographed using a digital camera. Data were analyzed statistically by ANOVA and Bonferroni test at 5% significance level and presented as mean ± SEM. ATV (9 mg/kg) caused a significant increase on gray tone variation of over 48% (118.3 ± 12.0 gray tones) when compared to saline (79.8 ± 6.2 gray tones), indicating greater radiographic density. These data were corroborated by macroscopic findings, where ATV (9 mg/kg) reduced alveolar bone loss by over 47% (p