Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography
Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography
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DOI：
10.1002/ccd.20717
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发表时间：
2006-06-01
影响因子：
2.3
通讯作者：
Feldman, Marc D.
中科院分区：
文献类型：
--
作者：
Cilingiroglu, Mehmet;Oh, Jung Hwan;Feldman, Marc D.
目的：本研究的目的是评价光学相干断层扫描(OCT)在已建立的人类动脉粥样硬化小鼠模型中识别易损斑块成分的可行性。背景：虽然尸检时预测斑块破裂的病理特征是众所周知的，但缺乏一种在活体内识别这些高危特征的技术。OCT使用反射光提供与组织学相似的斑块图像，分辨率高于竞争对手的成像方式。OCT能否可靠地识别动脉粥样硬化斑块的特征--纤细的纤维帽、大的脂核和动脉中高比例的脂类--还需要进一步的研究。方法：记录载脂蛋白E基因敲除小鼠(apoE(-/-))动脉粥样硬化的无名动脉节段的OCT图像，并与体内(n=7)和体外实验(n=12)的组织学对照。结果：OCT与组织学测量的纤维帽厚度、脂核大小和脂类含量百分比有很好的相关性。检查的纤维帽厚度跨越了已知断裂的人类纤维帽的厚度(
Objectives: The aim of this study was to evaluate the feasibility of optical coherence tomography (OCT) to identify the components of vulnerable plaques in a well-established murine model of human atherosclerosis. Background: Although the pathologic features that predict plaque rupture at autopsy are well known, the development of a technology to identify these high risk features in vivo is lacking. OCT uses reflected light to provide histology-like images of plaque with higher resolution than competing imaging modalities. Whether OCT can reliably identify the features of an atherosclerotic plaque that define it as vulnerable-thin fibrous cap, large lipid core, and high percent of lipid in the artery-requires further study. Methods: OCT images of the atherosclerotic innominate artery segments from the apolipoprotein E knockout (apoE(-/-)) mice were recorded and correlated with histology in both in vivo (n = 7) and well as in ex vivo experiments (n = 12). Results: Excellent correlation between the OCT and histology measurements for fibrous cap thickness, lipid core size, and percentage lipid content was found. The fibrous cap thicknesses examined span those of human fibrous caps known to rupture (