Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance.
Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance.
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DOI：
10.3171/foc.2003.15.1.2
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发表时间：
2003-07
影响因子：
4.1
通讯作者：
N. Pouratian;S. Sheth;S. Bookheimer;N. Martin;A. Toga
中科院分区：
文献类型：
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作者：
N. Pouratian;S. Sheth;S. Bookheimer;N. Martin;A. Toga
灌注依赖性脑映射模式，如功能性磁共振成像，正电子发射断层扫描，和内在信号的光学成像，已成为越来越受欢迎的神经外科指导，因为它们提供了一个相对快速和非侵入性的手段映射脑功能。这些模式是独特的，因为它们依赖于与神经元活动相结合的灌注相关信号来映射大脑，而不是测量电生理反应。因此，他们提出了独特的挑战，临床医生在理解的意义和限制，他们生产的地图。特别是，必须意识到这些地图的空间特异性，灵敏度和可靠性方面的模式的局限性，以及颅内病变的存在如何进一步复杂化这些问题。作者回顾了基于灌注的脑标测技术的发展、解释和局限性，特别关注脑标测的临床意义。
Perfusion-dependent brain mapping modalities, such as functional magnetic resonance imaging, positron emission tomography, and optical imaging of intrinsic signals, have become increasingly popular for neurosurgical guidance because they offer a relatively rapid and noninvasive means of mapping brain function. These modalities are unique because they rely on perfusion-related signals that are coupled with neuronal activity to map the brain instead of measuring electrophysiological responses. They consequently present unique challenges to the clinician in terms of understanding the significance and limitations of the maps they produce. In particular, one must be aware of limitations of the modalities with respect to spatial specificity, sensitivity, and reliability of these maps and how the presence of intracranial lesions may further complicate these issues. The authors review the evolution, interpretation, and limitations of perfusion-based brain mapping techniques, with special attention to clinical implications of the brain maps.