Concise Review: A Critical Evaluation of Criteria Used to Define Salivary Gland Stem Cells.
Concise Review: A Critical Evaluation of Criteria Used to Define Salivary Gland Stem Cells.
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简明评论：对用于定义唾液腺干细胞的标准的批判性评估。
DOI：
10.1002/stem.3046
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Ovitt,CatherineE
中科院分区：
文献类型：
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作者：
Weng,Pei-Lun;Aure,MaritH;Ovitt,CatherineE
在努力开发基于细胞的疗法来治疗唾液腺功能障碍的过程中，已经提出了成人唾液腺中许多不同的细胞群作为干细胞。这些细胞群根据所用的检测方法而变化，并且通常不重叠，从而得出结论，唾液腺含有多种干细胞。这篇综述的目的是批判性地评价用于鉴定成人唾液腺干细胞的检测方法和性质，并考虑每种方法的注意事项。重新评估定义标准可能有助于协调唾液腺中描述的许多潜在干细胞群，以增加研究之间的可比性并在该领域建立共识。StemCells2019; 37：1144- 1150显著性声明唾液腺中有许多不同且不重叠的细胞群被指定为成体干细胞。本研究的重点是用于定义这些细胞群的标准，并强调了与每个相关的限制。对各种细胞群的特征进行严格的重新评估可能有助于澄清哪些细胞可能对再生治疗有用。
In the effort to develop cell-based therapies to treat salivary gland dysfunction, many different populations of cells in the adult salivary glands have been proposed as stem cells. These cell populations vary, depending on the assay used, and are often nonoverlapping, leading to the conclusion that salivary glands harbor multiple stem cells. The goal of this review is to critically appraise the assays and properties used to identify stem cells in the adult salivary gland, and to consider the caveats of each. Re-evaluation of the defining criteria may help to reconcile the many potential stem cell populations described in the salivary gland, in order to increase comparability between studies and build consensus in the field. StemCells2019;37:1144–1150Significance StatementA number of diverse and nonoverlapping cell populations have been designated as adult stem cells in the salivary glands. The present study is focused on the criteria used to define these cell populations and highlights the limitations associated with each. A critical re-evaluation of how the various cell populations were characterized may serve to clarify which cells may be useful for regenerative therapy.