Thermosensitive liposomal drug delivery systems: state of the art review.
Thermosensitive liposomal drug delivery systems: state of the art review.
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DOI：
10.2147/ijn.s49297
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发表时间：
2014
影响因子：
8
通讯作者：
Hossann M
中科院分区：
文献类型：
--
作者：
Kneidl B;Peller M;Winter G;Lindner LH;Hossann M
当与局部热疗或高强度聚焦超声结合使用时，热敏脂质体是一种有前途的外部靶向药物至实体肿瘤的工具。体内结果已经证明了强有力的证据，即外部靶向比通过高度稳定的长循环药物制剂如聚乙二醇化脂质体多柔比星实现的被动靶向优越上级。截至2014年3月，Web of Science列出了该领域的371篇原创论文，仅2013年就有45篇。自1978年以来，已经开发了几种制剂，目前正在临床研究中的含有溶血磷脂的低温敏感脂质体。本文综述了热敏脂质体制剂的生物物理特性和体内功效的历史发展和特定的磷脂和表面活性剂的影响。此外，讨论了实体瘤的治疗策略。在这里，我们专注于温度触发血管内和间质药物释放。由磁共振成像引导的药物递送进一步增加了执行加热焦点的在线监测以计算局部释放的药物浓度并通过操纵加热体积和功率来外部控制药物释放的可能性。将外部靶向与热敏脂质体和磁共振引导的药物递送相结合将是这种纳米技术在医学上的独特特征。
Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.