CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD
CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD
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DOI：
10.1182/blood-2003-05-1500
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发表时间：
2004-01-15
期刊：
影响因子：
20.3
通讯作者：
Sackstein, R
中科院分区：
文献类型：
--
作者：
Milinkovic, M;Antin, JH;Sackstein, R
为了使循环淋巴细胞迁移到炎症部位，它们必须首先以足够的强度粘附到靶组织内皮，以克服血流的剪切力。我们以前报道，真皮乳头状血管在急性移植物抗宿主病（aGVHD）支持抗剪切淋巴细胞粘附。我们现在鉴定了指导这种结合的相关粘附分子，表明仅在aGVHD中真皮血管上表达的淋巴细胞CD 44和透明质酸（HA）之间的相互作用赋予这种抗剪切附着。天然HA沉积在血管内皮上支持淋巴细胞粘附，而固定在塑料上的HA则不支持。因此，在aGVHD中在真皮内皮处表达的HA专门用于在流动条件下支持淋巴细胞粘附，并且CD 44-HA相互作用可能有助于aGVHD中向皮肤的淋巴细胞嗜性。
For circulating lymphocytes to migrate to inflammatory sites, they must first adhere to the target tissue endothelium with sufficient strength to overcome the shear forces of blood flow. We previously reported that dermal papillary vessels in acute graft-versus-host disease (aGVHD) support shear-resistant lymphocyte adherence. We now identify the relevant adhesion molecule(s) directing this binding, showing that interactions between lymphocyte CD44 and hyaluronic acid (HA) expressed on dermal vessels in aGVHD alone confer this shear-resistant attachment. Native HA deposits on vascular endothelium support lymphocyte adherence, whereas HA immobilized on plastic does not. HA expressed at dermal endothelium in aGVHD is thus specialized to support lymphocyte adherence under flow conditions, and CD44-HA interactions may contribute to lymphocytotropism to skin in aGVHD.