Korsakoff's syndrome: a study of the relation between anterograde amnesia and remote memory impairment.
Korsakoff's syndrome: a study of the relation between anterograde amnesia and remote memory impairment.
复制标题
科尔萨科夫综合征：顺行性遗忘症与远期记忆障碍之间关系的研究。
DOI：
10.1037//0735-7044.100.2.165
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发表时间：
1986
影响因子：
1.9
通讯作者：
Squire,LR
中科院分区：
文献类型：
--
作者：
Shimamura,AP;Squire,LR
通过九项新学习能力测试和三项远程记忆测试对科尔萨科夫综合征患者进行评估，以确定顺行性遗忘与远程记忆障碍之间的相关性。顺行性遗忘症的严重程度与远期记忆损害的总体严重程度（1940 年代至 1970 年代）或更远的时间段（1940 年代至 1950 年代）观察到的损害之间没有相关性。然而，远期记忆障碍和顺行性遗忘之间的相关性随着时间段的临近而逐渐增强，并且仅在 1960 年代至 1970 年代或仅在 1970 年代就显着。结果支持这样的观点，即科尔萨科夫综合征的广泛远期记忆损伤至少部分不同于顺行性遗忘症，且与之无关。最近一段时间观察到的更严重的损伤可能与顺行性遗忘有关，因为它反映了近年来已经存在或逐渐发展的顺行性遗忘。因此，回忆非常遥远的事件的能力似乎取决于与新学习或回忆最近事件所需的大脑机制不同的大脑机制。
Patients with Korsakoff's syndrome were evaluated with nine tests of new learning ability and three tests of remote memory to determine the correlation between anterograde amnesia and remote memory impairment. There was no correlation between the severity of anterograde amnesia and either the overall severity of remote memory impairment (1940s–1970s) or the impairment observed for more remote time periods (1940s–1950s). However, the correlation between remote memory impairment and anterograde amnesia became progressively stronger with the recency of the time period and was significant for the 1960s–1970s or the 1970s alone. The results support the view that the extensive remote memory impairment in Korsakoff's syndrome is, at least in part, distinct from and unrelated to anterograde amnesia. The more severe impairment observed for more recent time periods could be related to anterograde amnesia in that it reflects anterograde amnesia that was either already in place or progressively developing during recent years. The ability to recall very remote events seems therefore to depend on brain mechanisms distinct from those required for new learning or for recall of more recent events.