The potential role of the mobile and non-coding genomes in adaptive response
The potential role of the mobile and non-coding genomes in adaptive response
复制标题
移动和非编码基因组在适应性反应中的潜在作用
DOI：
10.1016/j.tig.2022.08.006
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发表时间：
2023
影响因子：
11.4
通讯作者：
Godden A
中科院分区：
文献类型：
--
作者：
Godden A
连接小RNA（sRNA）和转座因子（TE）的严格调节的反馈环为在分子水平上对变化的环境做出适应性反应提供了机会。环境诱导的TE和sRNA谱的变化可能会影响编码基因的表达，并引发器官和跨代反应。了解这种联系可能会为物种如何适应不断变化的气候提供一个机械解释，并可能为生物医学和农业应用提供新的分子靶点。
The tightly regulated feedback loops linking small RNAs (sRNAs) and transposable elements (TEs) offer the opportunity for an adaptive response to changing environments at the molecular level. Environmentally induced changes in TE and sRNA profiles may affect expression of coding genes and trigger an organismic and transgenerational response. Understanding this link may provide a mechanistic explanation for how species can adapt to changing climates and may offer novel molecular targets for biomedical and agricultural applications.