Endothelial cell metabolism and implications for cancer therapy.
Endothelial cell metabolism and implications for cancer therapy.
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DOI：
10.1038/bjc.2012.398
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发表时间：
2012-10-09
影响因子：
8.8
通讯作者：
Harris, A. L.
中科院分区：
文献类型：
--
作者：
Harjes, U.;Bensaad, K.;Harris, A. L.
肿瘤组织的特点是波动的氧气浓度，减少营养供应，和酸性pH值。肿瘤细胞的主要糖酵解代谢有助于这一点，增加葡萄糖消耗和增加乳酸分泌。当内皮细胞被招募到肿瘤代谢环境时，会受到特别的挑战。它们需要增殖并形成功能网络，以建立连续的血液流动。考虑到代谢失调是癌症的一个新的标志和肿瘤治疗的目标，重要的是要纳入目前的知识，肿瘤代谢环境，作为一个治疗目标，如何影响内皮细胞代谢和血管生成反应。最近的研究表明，与其他正常或肿瘤组织相比，内皮细胞的代谢途径存在差异。因此，我们回顾了相关文献内皮代谢和代谢应激条件下血管生成激活的反应。
Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. The primarily glycolytic metabolism of tumour cells contributes to this, with increased glucose consumption and increased lactate secretion. Endothelial cells are particularly challenged when recruited towards the tumour metabolic environment. They are required to proliferate and form functional networks in order to establish continuous blood flow. Considering that deregulated metabolism is an emerging hallmark of cancer and target of tumour therapy, it is of importance to incorporate the current knowledge about how the tumour metabolic environment, as a therapy target, can affect endothelial cell metabolism and the angiogenic response. Recent studies have shown differences in metabolic pathways in endothelial cells compared with other normal or tumour tissues. Therefore, we have reviewed relevant literature on endothelial metabolism and the response to angiogenic activation in conditions of metabolic stress.
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影响因子：
8
作者：
Semenza, G. L.
通讯作者：
Semenza, G. L.
影响因子：
64.8
作者：
Guarani V;Deflorian G;Franco CA;Krüger M;Phng LK;Bentley K;Toussaint L;Dequiedt F;Mostoslavsky R;Schmidt MHH;Zimmermann B;Brandes RP;Mione M;Westphal CH;Braun T;Zeiher AM;Gerhardt H;Dimmeler S;Potente M
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Potente M
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5.7
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Kuemmerle NB;Rysman E;Lombardo PS;Flanagan AJ;Lipe BC;Wells WA;Pettus JR;Froehlich HM;Memoli VA;Morganelli PM;Swinnen JV;Timmerman LA;Chaychi L;Fricano CJ;Eisenberg BL;Coleman WB;Kinlaw WB
通讯作者：
Kinlaw WB
影响因子：
64.8
作者：
Hagberg, Carolina E.;Falkevall, Annelie;Eriksson, Ulf
通讯作者：
Eriksson, Ulf
影响因子：
33.6
作者：
Goel S;Duda DG;Xu L;Munn LL;Boucher Y;Fukumura D;Jain RK
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Jain RK