Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography
Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography
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DOI：
10.1364/boe.5.003684
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发表时间：
2014-10-01
影响因子：
3.4
通讯作者：
Taroni, Paola
中科院分区：
文献类型：
--
作者：
Quarto, Giovanna;Spinelli, Lorenzo;Taroni, Paola
介绍了恶性和良性乳腺病变的光学特征。通过7波长光学乳房X线摄影仪在630-1060 nm范围内进行时间分辨透射率测量，提供成像和光谱信息。共分析了62个病变，其中恶性病变33个，良性病变29个。应用基于病变内光子路径长度的高阶计算的扰动模型进行乳腺病变的表征，从而评估氧合血红蛋白和脱氧血红蛋白、脂质、水和胶原蛋白浓度。肿瘤和健康组织之间的显着差异，观察在吸收特性和成分浓度。特别是，良性病变和肿瘤在几个波长的吸收方面以及在氧合血红蛋白和胶原蛋白含量方面显示出统计学上显著的区别。(C)2014年美国光学学会
The optical characterization of malignant and benign breast lesions is presented. Time-resolved transmittance measurements were performed in the 630-1060 nm range by means of a 7-wavelength optical mammograph, providing both imaging and spectroscopy information. A total of 62 lesions were analyzed, including 33 malignant and 29 benign lesions. The characterization of breast lesions was performed applying a perturbation model based on the high-order calculation of the pathlength of photons inside the lesion, which led to the assessment of oxy- and deoxy-hemoglobin, lipids, water and collagen concentrations. Significant variations between tumor and healthy tissue were observed in terms of both absorption properties and constituents concentration. In particular, benign lesions and tumors show a statistically significant discrimination in terms of absorption at several wavelengths and also in terms of oxy-hemoglobin and collagen content. (C) 2014 Optical Society of America