The Influence of Depressive Symptoms on Quality of Life after Stroke: A Prospective Study
The Influence of Depressive Symptoms on Quality of Life after Stroke: A Prospective Study
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DOI：
10.1016/j.jstrokecerebrovasdis.2014.08.020
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发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Fraguas, Renerio
中科院分区：
文献类型：
--
作者：
Guajardo, Valeri Delgado;Terroni, Luisa;Fraguas, Renerio
背景：中风后抑郁症状可以前瞻性地预测健康相关生活质量（HRQOL）的损害。然而，尚不清楚这种预测效果是否独立于中风后 1 个月的 HRQOL。本研究旨在调查中风后 1 个月和 3 个月的抑郁症状对中风后 3 个月 HRQOL 的影响，并调查中风后 1 个月测量的 HRQOL 对这些关系的影响。方法：我们对连续住进教学医院神经内科病房的 106 名符合条件的患者中的 67 名患者进行了前瞻性评估，这些患者在首次缺血性卒中后 1 个月和 3 个月时。精神科医生使用包含 31 项的汉密尔顿抑郁评定量表评估抑郁症状的存在，并使用来自医疗结果研究的包含 36 项的简短健康调查来评估 HRQOL。我们使用线性回归来衡量抑郁症状、1 个月 HRQOL 以及潜在混杂因素对 3 个月 HRQOL 的影响。结果：我们发现中风后 1 个月的抑郁症状与 3 个月的 HRQOL 之间存在关联；然而，在调整卒中后 1 个月 HRQOL 时，这种关联并不显着。 3 个月时的抑郁症状与卒中后 3 个月时的 HRQOL 相关，独立于卒中后 1 个月时的 HRQOL 和潜在的混杂因素。结论：当前 3 个月时的抑郁症状对于卒中后 3 个月的 HRQOL 很重要；然而，就前瞻性预测而言，1 个月的 HRQOL 是最相关的因素。
Background: Poststroke depressive symptoms have prospectively predicted impairment of health-related quality of life (HRQOL). However, it is not known whether such predictive effect is independent of HRQOL at 1 month after stroke. This study aimed to investigate the impact of depressive symptoms at 1 and 3 months after stroke on the 3-month poststroke HRQOL and to investigate the influence of the HRQOL measured at 1 month after stroke on these relationships. Methods: We prospectively evaluated 67 patients at 1 and 3 months after a first-ever ischemic stroke from 106 eligible patients who have been consecutively admitted to the neurology ward of a teaching hospital. A psychiatrist assessed the presence of depressive symptoms using the 31-item version of the Hamilton Rating Scale for Depression and the HRQOL was assessed with the 36-item Short-Form Health Survey from the Medical Outcomes Study. We used linear regression to measure the impact of depressive symptoms, HRQOL at 1 month, and potential confounders on HRQOL at 3 months. Results: We found an association between depressive symptoms at 1 month and HRQOL at 3 months after the stroke; however, this association was not significant when adjusting for the 1 month poststroke HRQOL. Depressive symptoms at 3 months were associated with HRQOL at 3 months after stroke, independently of the poststroke HRQOL at 1 month and potential confounders. Conclusions: Current depressive symptoms at 3 months are important for HRQOL at 3 months after stroke; however, regarding the prospective prediction, HRQOL at 1 month is the most relevant factor.