Structure and Function of the Escherichia coli Thermosensors.
Structure and Function of the Escherichia coli Thermosensors.
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大肠杆菌热传感器的结构和功能。
DOI：
10.2142/biophys.39.223
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
I. Kawagishi
中科院分区：
文献类型：
--
作者：
S. Nishiyama;M. Homma;I. Kawagishi
大肠杆菌中的趋热性作为研究热敏机制的模型系统。对信号转导电路中涉及的所有元器件进行了识别。温度传感器是一种跨膜蛋白，最初被鉴定为化学感受器。它们调节细胞质组氨酸激酶CHEA的活性。最近的研究揭示了这些“温度计蛋白”的一些独特和意想不到的特征，包括受体共价修饰对温度敏感特性的影响，以及在某些条件下细胞内外结构域的解偶联。为了了解它们的化学传感机制，还需要对传感器的热敏特性进行研究。
Thermotaxis in Escherichia coli as a model system for studying thermosensing mechanisms. All the components involved in the signal transduction circuit have been indentified. Thermosensors are the transmembrane proteins that were originally indentified as chemoreceptors. They regulate the activity of the cytoplasmic histidine kinase CheA. Recent studies revealed some unique and unexpected features of these "thermometer proteins", including effects of receptor covalent modification on thermosensing properties, and uncoupling of intra- and extracellular domains under some conditions. Investigation of thermosensing properties of the sensors should also be required for understanding their chemosensing mechanisms.