Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor
Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor
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DOI：
10.1097/wnr.0b013e32835b373b
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发表时间：
2012-12-19
期刊：
影响因子：
1.7
通讯作者：
Sato, Takaaki
中科院分区：
文献类型：
--
作者：
Murakami, Toyotaka;Matsukawa, Mutsumi;Sato, Takaaki
捕食者的气味，如2，5-二氢-2，4，5-三甲基噻唑啉（TMT），在一些啮齿动物中诱导应激样行为，并且存在包括前梨状皮质（APC）和终纹床核（BST）在内的复杂混合脑区的激活。相反，玫瑰气味可以抵消TMT诱导的APC腹吻侧部分和BST内侧部分的激活。在本研究中，两种新的气味，木质（扁柏酚）和香菜[S（+）-香芹酮]气味，进行了评估，以确定它们是否具有抗应激作用。血浆促肾上腺皮质激素水平，应激标志物，和c-Fos免疫阳性细胞的数量进行了测定，在APC和BST。血浆促肾上腺皮质激素水平增加TMT单独和与S（+）-香芹酮组合，然而，扁柏酚与或不与TMT没有效果。TMT单独及与S（+）-香芹酮或扁柏酚合用均能增加BST内侧部的活化细胞数。虽然TMT单独激活BST的内侧部分，但TMT和扁柏酚的混合物激活BST的内侧和外侧部分。这些数据表明，选择性反应TMT在BST的内侧部分被掩盖了更多的气味相关区域的扁柏酚与TMT的激活。此外，内侧与外侧BST激活的比例可能在应力相关行为中至关重要。总之，扁柏酚可以减轻TMT诱导的压力，然而，其潜在的机制似乎是不同的玫瑰气味，在我们以前的研究中发现。NeuroReport 23：1071-1076（C）2012 Wolters Kluwer Health \ Lippincott威廉姆斯& Wilkins。
Predator odors, such as 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), induce a stress-like behavior in some rodents, and there is activation of a complex mix of brain regions including the anterior piriform cortex (APC) and the bed nucleus of stria terminalis (BST). In contrast, rose odor can counteract TMT-induced activation of the ventrorostral part of APC and the medial part of BST. In the present study, two novel odors, woody (hinokitiol) and caraway [S(+)-carvone] odors, were evaluated to determine whether they have an antistress effect. Plasma adrenocorticotropic hormone levels, a marker of stress, and the number of c-Fos-immunopositive cells were determined in APC and BST. Plasma adrenocorticotropic hormone levels were increased by TMT alone and in combination with S(+)-carvone; however, hinokitiol with or without TMT did not have an effect. The number of activated cells in the medial part of BST was increased by TMT alone and in combination with S(+)-carvone or hinokitiol. Although TMT alone activated the medial part of BST, a mixture of TMT and hinokitiol activated both the medial and the lateral part of BST. These data suggest that the selective responses to TMT in the medial part of BST were obscured by activation of more odor-related regions by hinokitiol with TMT. In addition, the ratio of medial to lateral BST activation may be critical in stress-related behavior. In conclusion, hinokitiol can alleviate TMT-induced stress; however, the underlying mechanism appears to be different from that of the rose odor, as found in our previous study. NeuroReport 23:1071-1076 (C) 2012 Wolters Kluwer Health \ Lippincott Williams & Wilkins.