A Novel Association of Biventricular Cardiac Noncompaction and Diabetic Embryopathy: Case Report and Review of the Literature
A Novel Association of Biventricular Cardiac Noncompaction and Diabetic Embryopathy: Case Report and Review of the Literature
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双心室心脏致密化不全与糖尿病胚胎病的新关联：病例报告和文献综述
DOI：
10.2350/14-07-1532-cr.1
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发表时间：
2015
影响因子：
1.9
通讯作者：
M. Fishbein
中科院分区：
文献类型：
--
作者：
Jennifer S. Woo;M. Perez‐Rosendahl;Dana Haydel;G. Perens;M. Fishbein
Diabetic embryopathy refers to a constellation of congenital malformations arising in the setting of poorly controlled maternal diabetes mellitus. Cardiac abnormalities are the most frequently observed findings, with a 5-fold risk over normal pregnancies. Although a diverse spectrum of cardiac defects has been documented, cardiac noncompaction morphology has not been associated with this syndrome. In this report, we describe a novel case of biventricular cardiac noncompaction in a neonate of a diabetic mother. The patient was a late preterm female with right anotia, caudal dysgenesis, multiple cardiac septal and aortic arch defects, and biventricular cardiac noncompaction. Examination of both ventricles demonstrated spongy myocardium with increased myocardial trabeculation greater than 50% left ventricular thickness and greater than 75% right ventricular thickness, with hypoplasia of the bilateral papillary muscles, consistent with noncompaction morphology. Review of the literature highlights the importance of gene expression and epigenomic regulation in cardiac embryogenesis.
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Msx2 是小鼠心脏神经嵴发育过程中 Pax3 的直接下游效应器。
DOI：
10.1242/dev.129.2.527
发表时间：
2002
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Kwang,StanfordJ;Brugger,SeanM;Lazik,Arthur;Merrill,AmyE;Wu,Lan-Ying;Liu,Yi-Hsin;Ishii,Mamoru;Sangiorgi,FrankO;Rauchman,Michael;Sucov,HenryM;Maas,RichardL;MaxsonJr,RobertE
通讯作者：
MaxsonJr,RobertE
影响因子：
10.5
作者：
Jiao, K;Kulessa, H;Hogan, BLM
通讯作者：
Hogan, BLM
影响因子：
20.1
作者：
Lee, Y;Song, AJ;Lyons, GE
通讯作者：
Lyons, GE
影响因子：
24
作者：
Vatta, M;Mohapatra, B;Towbin, JA
通讯作者：
Towbin, JA
影响因子：
9.8
作者：
Correa, Adolfo;Gilboa, Suzanne M.;Reece, E. Albert
通讯作者：
Reece, E. Albert