Total Synthesis of the Marine Sponge Alkaloid Motuporamine C Using a Ramberg-Backlund Ring Contraction Strategy
Total Synthesis of the Marine Sponge Alkaloid Motuporamine C Using a Ramberg-Backlund Ring Contraction Strategy
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DOI：
10.1002/slct.202202991
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发表时间：
2022-10-26
期刊：
影响因子：
2.1
通讯作者：
Wang，Quanrui
中科院分区：
文献类型：
--
作者：
Song，Zijie;Meng，Shuyu;Wang，Quanrui
本文报道了一种新的从海洋海绵Xestospongia exigua中提取的大环多胺生物碱motuporamine C的全合成方法。该合成的关键步骤包括应用兰贝格-Bäcklund重排来实现15元氮杂-大环烯烃和Rh（II）催化的环氧化物脱氧以将环状结构中的双键的E-构型转化为Z-构型。
A new total synthesis of the marine alkaloid motuporamine C, a macrocyclic polyamine alkaloid from the marine spongeXestospongia exigua, has been accomplished. Key steps of this synthesis include application of Ramberg‐Bäcklund rearrangement for achieving the 15‐membered aza‐macrocyclic alkene and Rh(II)‐catalyzed deoxygenation of epoxide for the conversion ofE‐ toZ‐configuration of the double bond within the cyclic structure.