Attention deficit in depressed suicide attempters
Attention deficit in depressed suicide attempters
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DOI：
10.1016/j.psychres.2007.08.020
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发表时间：
2008-05-30
影响因子：
11.3
通讯作者：
Mann, J. John
中科院分区：
文献类型：
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作者：
Keilp, John G.;Gorlyn, Marianne;Mann, J. John
抑郁症患者的注意力通常会受到损害，并且可能会增加自杀行为的风险。在这项研究中，对 66 名非患者、83 名没有自杀企图历史的抑郁症受试者、53 名有过一次或多次低致命性自杀企图的抑郁症受试者和 42 名至少有一次高致命性自杀企图的抑郁症受试者进行了两项计算机化注意力测量、连续表现测试 (CPT) 和 Stroop 任务的比较。所有受试者在评估时均未服用药物。所有抑郁症受试者的注意力都受到损害，但有自杀行为史的受试者的注意力更严重。各组之间的 CPT 表现没有差异，但与非患者相比，所有抑郁症受试者的斯特鲁普干扰明显较差，而与所有其他组相比，高致死率自杀未遂者的斯特鲁普干扰更差。干扰分数与主观抑郁、功能水平、自杀意念、过去自杀企图的次数以及过去自杀企图的致死率有一定的相关性。对于那些有自杀行为史的人来说，与抑郁症相关的注意力障碍，尤其是对干扰的易感性，会更加严重。注意力控制的基本缺陷可能会导致自杀行为的风险，并可能导致自杀患者的各种认知缺陷。有助于注意力控制的大脑区域与情感障碍相关区域有相当大的重叠，对于寻求表征与自杀行为相关的神经心理因素的研究来说，可能是一个有用的目标。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Attention is typically impaired in depression and may play a role in risk for suicidal behavior. In this study, 66 non-patients, 83 depressed subjects with no past history of suicide attempt, 53 depressed subjects with one or more low lethality suicide attempts, and 42 depressed subjects with at least one high lethality attempt were compared on two computerized measures of attention, a continuous performance test (CPT) and a Stroop task. All subjects were medication free at the time of assessment. Attention was impaired in all depressed subjects but worse in those with a past history of suicidal behavior. CPT performance did not differ among the groups, but Stroop interference was significantly poorer in all depressed subjects relative to non-patients, and poorer still in high lethality suicide attempters relative to all other groups. Interference scores correlated modestly with subjective depression, functional level, suicide ideation, number of past suicide attempts, and lethality of past attempts. Depression-related impairments of attention, especially susceptibility to interference, are accentuated in those with a past history of suicidal behavior. Fundamental deficits in attentional control may play a role in risk for suicidal behavior, and may contribute to a variety of cognitive deficits in suicidal patients. Brain regions subserving attentional control, which overlap considerably with regions implicated in affective disorders, may be a useful target for studies seeking to characterize neuropsychological factors associated with suicidal behavior. (c) 2007 Elsevier Ireland Ltd. All rights reserved.