Assessment of pulmonary arterial pressure by velocity-encoded cine magnetic resonance imaging in children with congenital heart disease.
Assessment of pulmonary arterial pressure by velocity-encoded cine magnetic resonance imaging in children with congenital heart disease.
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DOI：
10.1253/circj.cj-13-0626
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发表时间：
2013-11
期刊：
影响因子：
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通讯作者：
M. Sugimoto;H. Kajino;Aya Kajihama;Kouichi Nakau;Noboru Murakami;H. Azuma
中科院分区：
文献类型：
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作者：
M. Sugimoto;H. Kajino;Aya Kajihama;Kouichi Nakau;Noboru Murakami;H. Azuma
最近有报道称，速度编码电影磁共振成像（VEC-MRI）不仅可以有效评估成人肺血流量（Qp），还可以评估肺动脉压（PAP）。然而，很少有关于VEC-MRI在评估先天性心脏病（CHD）患儿PAP的有效性的报道。方法与结果对34例冠心病患儿进行评估。Qp和全身血流量（Qs）通过心导管和VEC-MRI测定。采用肺灌注显像和VEC-MRI检测左、右Qp比（R/L）。通过心导管插管测定肺-体压比（Pp/Ps）。以体表面积标准化肺动脉加速时间（AcT）、射血时间（ET）、峰值速度（PV）、加速体积（AcV）和最大射血流速变化（MCFR），采用VEC-MRI测定。根据Pp/Ps将患儿分为两组。VEC-MRI测得的Qs、R/L比和Qp/Qs与导管置管和显像测得的Qp/Qs呈正相关。两组间AcT、ET、AcT/ET、PV、AcV均无显著差异。然而，在MCFR中观察到显著差异。此外，MCFR与Pp/Ps之间存在显著相关性。结论：本研究清楚地表明，通过参考儿童MCFR， VEC-MRI不仅可用于评估血流量，还可用于评估PAP。
BACKGROUND Velocity-encoded cine magnetic resonance imaging (VEC-MRI) has recently been reported as effective for assessing not only pulmonary blood flow (Qp) but also pulmonary arterial pressure (PAP) in adults. However, there have been few reports on the usefulness of VEC-MRI for assessing PAP in children with congenital heart disease (CHD). METHODS AND RESULTS We evaluated 34 children with CHD. Qp and systemic blood flows (Qs) were determined by cardiac catheterization and VEC-MRI. The right-to-left Qp ratio (R/L) was measured by pulmonary perfusion scintigraphy and VEC-MRI. The pulmonary-to-systemic blood pressure ratio (Pp/Ps) was determined by cardiac catheterization. The acceleration time (AcT), ejection time (ET), peak velocity (PV), acceleration volume (AcV), and maximal change in flow rate during ejection (MCFR) in the pulmonary arteries, which were standardized by body surface area, were determined by VEC-MRI. The children were divided into 2 groups according to Pp/Ps. The Qs, R/L ratio and Qp/Qs obtained by VEC-MRI strongly correlated with those obtained by catheterization and scintigraphy. No significant differences in AcT, ET, AcT/ET, PV, or AcV were observed between the 2 groups. However, a significant difference was observed in MCFR. Furthermore, a significant correlation was observed between the MCFR and Pp/Ps. CONCLUSIONS This study clearly demonstrated that VEC-MRI is useful for assessing not only blood flow, but also PAP, by referring to MCFR in children.