Tick modulation of host immunity: an important factor in pathogen transmission
Tick modulation of host immunity: an important factor in pathogen transmission
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DOI：
10.1016/s0020-7519(99)00042-9
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发表时间：
1999-06-01
影响因子：
4
通讯作者：
Wikel, SK
中科院分区：
文献类型：
--
作者：
Wikel, SK
蜱-宿主界面的免疫相互作用涉及蜱的先天性和特异性获得性宿主免疫防御和免疫调节对策。蜱喂食刺激宿主免疫应答途径，涉及抗原呈递细胞、细胞因子、B细胞、T细胞、循环和亲同型细胞抗体、粒细胞和一系列生物活性分子。为了响应宿主免疫防御，蜱介导的宿主免疫抑制对策抑制：宿主抗体应答;补体激活; T细胞增殖;以及巨噬细胞和Th 1淋巴细胞的细胞因子产生。在蜱唾液腺和唾液中鉴定的免疫抑制蛋白质已部分鉴定。蜱诱导的宿主免疫抑制促进血餐采集，并且是蜱传播的致病因子伯氏疏螺旋体传播/建立的重要因素。提出了一种控制蜱传病原体的新策略。(C)1999年澳大利亚寄生虫学会由爱思唯尔科技有限公司出版。保留所有权利。
Immunological interactions at the tick-host interface involve innate and specific acquired host immune defenses and immunomodulatory countermeasures by the tick. Tick feeding stimulates host immune response pathways involving antigen-presenting cells, cytokines, B-cells, T-cells, circulating and homocytotropic antibodies, granulocytes, and an array of biologically active molecules. In response to host immune defenses, tick-mediated host immunosuppressive countermeasures inhibit: host antibody responses; complement activation; T-cell proliferation; and cytokine elaboration by macrophages and Th1-lymphocytes. Immunosuppressive proteins identified in tick salivary glands and saliva have been partially characterised. Tick-induced host immunosuppression facilitates blood meal acquisition and is an important factor in the transmission/establishment of the tick-borne disease-causing agent, Borrelia burgdorferi. A novel strategy for control of tick-borne pathogens is proposed. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.