AVPV1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters
AVPV1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters
复制标题
DOI：
10.1016/j.pbb.2004.10.024
复制
发表时间：
2005-01-01
影响因子：
3.6
通讯作者：
Blanchard, DC
中科院分区：
文献类型：
--
作者：
Blanchard, RJ;Griebel, G;Blanchard, DC
精氨酸抗利尿激素（AVP）与应激的多种生理和行为反应有关。受体选择性AVP激动剂和拮抗剂化合物的合成允许对特定受体亚型在这些反应中的具体作用进行差异分析。本研究采用常驻-入侵者模式，研究了最近合成的AVP V-1b选择性拮抗剂SSR149415对雄性叙利亚仓鼠进攻性攻击的影响。对驻地仓鼠口服1、10或30 mg/kg的SSR149415，然后评估面对入侵者的驻地仓鼠的一系列攻击相关措施。10和30 mg/kg剂量显著减少了攻击性侧身行为和追逐行为的持续时间，30 mg/kg剂量也显著减少了追逐次数。10和30 mg/kg的剂量也显著减少嗅觉调查的频率和持续时间以及侧翼标记的持续时间。这些发现表明，V1b受体的活性与攻击性攻击的调节之间存在联系。这些发现与先前关于V-1b受体作用的研究一致，表明该受体的拮抗作用可能有助于调节对高压力或威胁条件的一系列情绪反应。(C) 2004爱思唯尔公司版权所有。
Arginine vasopressin (AVP) has been implicated in a variety of physiological and behavioral responses to stress. Synthesis of receptor-selective AVP agonist and antagonist compounds allows differential analysis of the specific roles of particular receptor subtypes with respect to these responses. Here, effects of the recently synthesized AVP V-1b selective antagonist, SSR149415, were examined for offensive aggression in male Syrian hamsters, using a resident-intruder paradigm. Oral administration of vehicle or 1, 10, or 30 mg/kg of SSR149415 to resident hamsters was followed by evaluation of a range of aggression-related measures of residents confronted by intruders. The 10 and 30 mg/kg doses significantly reduced the duration of offensive sideways and chase behaviors, and the 30 mg/kg dose also reduced chase frequency. The 10 and 30 mg/kg dose also significantly reduced frequency and duration of olfactory investigation and duration of flank marking. These findings suggest a link between activity of the V1b receptor and the modulation of offensive aggression. These findings agree with previous research on V-1b receptor effects in suggesting that antagonism of this receptor may be useful in modulating a range of emotional responses to highly stressful or threatening conditions. (C) 2004 Elsevier Inc. All rights reserved.