Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets
Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets
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DOI：
10.1038/s41593-019-0452-x
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发表时间：
2019-07
影响因子：
25
通讯作者：
C. L. Wee;Maxim Nikitchenko;Wei-chun Wang;Sasha J. Luks-Morgan;E. Song;James A. Gagnon;Owen Randlett;I. H. Bianco;Alix M. B. Lacoste;Elena Glushenkova;Joshua P. Barrios;A. Schier;S. Kunes;F. Engert;A. Douglass
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文献类型：
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作者：
C. L. Wee;Maxim Nikitchenko;Wei-chun Wang;Sasha J. Luks-Morgan;E. Song;James A. Gagnon;Owen Randlett;I. H. Bianco;Alix M. B. Lacoste;Elena Glushenkova;Joshua P. Barrios;A. Schier;S. Kunes;F. Engert;A. Douglass
秀丽线虫是仅有的两种绘制了整个神经系统连接组的动物之一。因此，蠕虫中的每个突触都是已知的，这使得研究人员能够剖析控制正常和异常行为的神经回路。发表在《自然》杂志上的一项新资源重建了线虫连接体，以区分两种蠕虫--成年两性蠕虫和成年雄性蠕虫。该资源绘制了神经元之间、神经元和肌肉之间以及肌肉之间的联系。两性动物有302个神经元，而雄性有更多的神经元-385个。连接体还包括关于这些神经元连接有多“强大”的细节。参与繁殖的神经元在性别之间有明显的不同，但其他一些非生殖回路也是如此。EPN
Caenorhabditis elegans is one of just two animals to have had its entire nervous system connectome mapped. Every synapse is thus known in the worm, allowing researchers to dissect the neural circuity that controls normal and abnormal behavior. A new resource published in Nature reconstructs the C. elegans connectome, to distinguish between the two worm sexes—an adult hermaphrodite and an adult male.The resource diagrams the connections between neurons, between neurons and muscles; and between muscles. Hermaphrodites have 302 neurons, while males have a few more—385. The connectome also includes detail about how ‘strong’those neuronal connections are. Those involved in reproduction were notably different between the sexes, but so too were a number of other nonreproductive circuits. EPN