Salvianolic Acid B, a potential chemopreventive agent, for head and neck squamous cell cancer.
Salvianolic Acid B, a potential chemopreventive agent, for head and neck squamous cell cancer.
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Salvianolic Acid B，一种潜在的化学预防剂，用于头颈鳞状细胞癌。
DOI：
10.1155/2011/534548
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发表时间：
2011
影响因子：
--
通讯作者：
Gu X
中科院分区：
文献类型：
--
作者：
Zhao Y;Guo Y;Gu X
头颈部鳞状细胞癌（HNSCC）是美国十大癌症之一。在过去二十年里，头颈部鳞状细胞癌的生存率仅有小幅提升。此外，非裔美国男性在这种可预防疾病上承受着不成比例的沉重负担。因此，有必要应对预防性健康措施方面的重大挑战。丹酚酸B（Sal - B）提取自丹参，丹参是一种著名的中药，数千年来一直被安全用于治疗和预防衰老相关疾病。最近，丹酚酸B的抗癌特性受到了更多关注。在培养的头颈部鳞状细胞癌细胞以及头颈部鳞状细胞癌异种移植动物模型中，丹酚酸B都能显著抑制或延缓头颈部鳞状细胞癌的生长。已提出以下抗癌机制：抑制环氧化酶 - 2（COX - 2）/前列腺素E - 2（PGE - 2）通路、促进细胞凋亡以及调节血管生成。总之，丹酚酸B是一种潜在的头颈部鳞状细胞癌化学预防剂，通过抗氧化和抗炎机制发挥作用。
Head and neck squamous cell cancer (HNSCC) is one of the top ten cancers in the United States. The survival rate of HNSCC has only marginally improved over the last two decades. In addition, African-American men bear a disproportionate burden of this preventable disease. Therefore, a critical challenge of preventive health approaches is warranted. Salvianolic acid B (Sal-B) isolated from Salvia miltiorrhiza Bge, which is a well-know Chinese medicines has been safely used to treat and prevent aging diseases for thousand of years. Recently, the anticancer properties of Sal-B have received more attention. Sal-B significantly inhibits or delays the growth of HNSCC in both cultured HNSCC cells and HNSCC xenograft animal models. The following anticancer mechanisms have been proposed: the inhibition of COX-2/PGE-2 pathway, the promotion of apoptosis, and the modulation of angiogenesis. In conclusion, Sal-B is a potential HNSCC chemopreventive agent working through antioxidation and anti-inflammation mechanisms.