Normal neuroanatomical variation in the human brain: An MRI-volumetric study
Normal neuroanatomical variation in the human brain: An MRI-volumetric study
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DOI：
10.1002/ajpa.10092
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发表时间：
2002-08-01
影响因子：
2.8
通讯作者：
Grabowski, TJ
中科院分区：
文献类型：
--
作者：
Allen, JS;Damasio, H;Grabowski, TJ
关于人脑体内大小及其主要解剖学定义细分的规范数据不容易获得。在这项研究中，使用高分辨率磁共振成像来测量46名正常的右撇子成年人（23名男性，23名女性）22-49岁之间的区域脑体积。大脑的分析是基于神经解剖的地标。测量了以下大脑区域：大脑半球，额叶，颞叶，顶叶，枕叶，扣带回回，岛状，岛状，小脑，call体和侧心室。对于整个大脑及其几乎所有主要细分（包括call体），男性往往比女性大得多。然而，在男性和女性中，相对于半球的总体积相对于区域的比例大小相似。区域大小的变化总是大于比例表示的变化。除了扣带回的回，脑部区域的不对称性并不深刻，腰部在左半球较大。大脑区域的大小高度相关，除了外侧心室。控制半球大小后，额叶和顶叶的体积显着相关。枕叶的性二态性往往比其他主要叶更小，并且与其他大脑区域的相关性较小。这些结果对理解大脑的某些部门是否表现出在人类和人类进化过程中的相对扩展具有意义。 （c）2002 Wiley-Liss，Inc。
Normative data on the in vivo size of the human brain and its major anatomically defined subdivisions are not readily available. In this study, high-resolution magnetic resonance imaging was used to measure regional brain volumes in 46 normal, right-handed adults (23 men, 23 women) between the ages of 22-49 years. Parcellation of the brain was based on neuroanatomical landmarks. The following brain regions were measured: the cerebral hemispheres, frontal lobe, temporal lobe, parietal lobe, occipital lobe, cingulate gyrus, insula, cerebellum, corpus callosum, and lateral ventricles. Males tend to be significantly larger than females, for the whole brain and for nearly all of its major subdivisions, including the corpus callosum. However, the proportional sizes of regions relative to total volume of the hemisphere are re markably similar in males and females. Variation in size of region is always greater than variation in proportional representation. Asymmetries in brain regions are not profound, with the exception of the cingulate gyrus, which is larger in the left hemisphere. Brain regions are highly correlated in size, with the exception of the lateral ventricles. After controlling for hemisphere size, the volumes of the frontal and parietal lobes are significantly negatively correlated. The occipital lobe tends to be less sexually dimorphic than other major lobes, and less correlated with other brain regions for volume. These results have implications for understanding whether or not certain sectors of the brain have shown relative expansion over the course of hominid and hominoid evolution. (C) 2002 Wiley-Liss, Inc.