Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness.
Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness.
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DOI：
10.1016/j.nlm.2015.10.013
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发表时间：
2016-03
影响因子：
2.7
通讯作者：
Gage FH
中科院分区：
文献类型：
--
作者：
Johnston ST;Shtrahman M;Parylak S;Gonçalves JT;Gage FH
海马成年神经发生被认为是促进模式分离的过程，在这个过程中，相似的神经元输入模式被转化为不同的神经元表征，从而允许在海马依赖任务中区分高度相似的刺激。然而，未成熟成年出生的齿状颗粒神经元细胞（abDGCs）发挥这一功能的机制尚不清楚。关于abDGC功能的两种理论，一种认为abDGC调节和稀疏齿状回的活动，另一种认为abDGC作为自主编码单元，通常被认为是相互排斥的。这两种机制在动态调节记忆分辨率的同时，避免了记忆干扰，保持了记忆的稳健性。
Hippocampal adult neurogenesis is thought to subserve pattern separation, the process by which similar patterns of neuronal inputs are transformed into distinct neuronal representations, permitting the discrimination of highly similar stimuli in hippocampus-dependent tasks. However, the mechanism by which immature adult-born dentate granule neurons cells (abDGCs) perform this function remains unknown. Two theories of abDGC function, one by which abDGCs modulate and sparsify activity in the dentate gyrus and one by which abDGCs act as autonomous coding units, are generally suggested to be mutually exclusive. This review suggests that these two mechanisms work in tandem to dynamically regulate memory resolution while avoiding memory interference and maintaining memory robustness.