OBSERVATIONS ON THE MECHANISM OF DECREASED TUBULAR REABSORPTION OF SODIUM AND WATER DURING SALINE LOADING.
OBSERVATIONS ON THE MECHANISM OF DECREASED TUBULAR REABSORPTION OF SODIUM AND WATER DURING SALINE LOADING.
复制标题
盐水负荷期间管状钠和水重吸收减少机制的观察。
DOI：
10.1172/jci105067
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发表时间：
1964
影响因子：
15.9
通讯作者：
R. Friedler
中科院分区：
文献类型：
--
作者：
L. E. Early;R. Friedler
波士顿，马萨诸塞州）最近的几项研究表明，钠排泄的调节涉及除钠的总滤过负荷和盐皮质激素的肾小管效应以外的因素。与早期的建议相反，即钠的滤过负荷的增加可能足以解释狗中盐负荷的钠尿排泄，de Wardener，米尔斯，Chapman和Hayter（1）报告说，对接受外源性盐皮质激素的狗给予盐导致钠的排泄增加。
Boston, Mass.) It has been demonstrated by several recent studies that the regulation of sodium excretion involves factors other than the total filtered load of sodium and the renal tubular effects of mineralocorticoids. Contrary to earlier suggestions that an increase in the filtered load of sodium may be sufficient to account for the natriuresis of saline loading in the dog, de Wardener, Mills, Chapman, and Hayter (1) reported that the administration of saline to dogs receiving an exogenous mineralocorticoid results in an increased excretion of so