Minireview: Timely ovulation: Circadian regulation of the female hypothalamo-pituitary-gonadal axis
Minireview: Timely ovulation: Circadian regulation of the female hypothalamo-pituitary-gonadal axis
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DOI：
10.1210/en.2005-1311
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发表时间：
2006-03-01
期刊：
影响因子：
4.8
通讯作者：
Schwartz, WJ
中科院分区：
文献类型：
--
作者：
de la Iglesia, HO;Schwartz, WJ
排卵前LH分泌的激增是由神经内分泌整合机制决定的，包括卵巢雌二醇水平和内源性昼夜节律系统。在雌性大鼠和仓鼠中的研究已经确定，下丘脑视交叉上核中的生物钟在设置LH峰中具有突出的作用，解剖学、生理学和药理学数据揭示了视交叉上核神经元与GnRH和雌二醇受体区域之间的负责任联系。最近的研究表明，GnRH和垂体细胞表达的生物钟基因可能在GnRH信号的释放和接收中发挥作用。LH峰的昼夜节律调节的分析可能提供一个模型，了解如何在其他神经内分泌轴多神经振荡器的功能。
The preovulatory surge in the secretion of LH is timed by a neuroendocrine integrative mechanism that involves ovarian estradiol levels and the endogenous circadian system. Studies in female rats and hamsters have established that the clock in the hypothalamic suprachiasmatic nucleus has a preeminent role in setting the LH surge, and anatomical, physiological, and pharmacological data are revealing the responsible connections between suprachiasmatic nucleus neurons and GnRH and estradiol-receptive areas. Recent investigations show that GnRH and pituitary cells express circadian clock genes that might play a role in the release and reception of the GnRH signal. Analysis of the circadian regulation of the LH surge may provide a model for understanding how multiple neural oscillators function within other neuroendocrine axes.