Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products
Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products
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DOI：
10.1021/acs.orglett.0c00577
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发表时间：
2020-04-17
期刊：
影响因子：
5.2
通讯作者：
Kozlowski, Marisa C.
中科院分区：
文献类型：
--
作者：
Gilmartin, Philip H.;Kozlowski, Marisa C.
介绍了一种温和、高效的钒催化自由酚分子内偶联反应方法。相应的苯酚-二烯酮产物以良好的产率和低催化剂负载量直接制备。电子多样性栓系酚前体的耐受性良好，催化方法有效地应用于三种天然产物和合成有用的吗啡喃生物碱前体的合成中作为关键步骤。
A mild and efficient method for the vanadium-catalyzed intramolecular coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.