A PET study of sequential finger movements of varying length in patients with Parkinson's disease
A PET study of sequential finger movements of varying length in patients with Parkinson's disease
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DOI：
10.1093/brain/122.3.483
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发表时间：
1999-03-01
期刊：
影响因子：
14.5
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Catalan, MJ;Ishii, K;Hallett, M
为研究帕金森病患者进行长序列运动的困难，我们使用（H₂O）-O - 15正电子发射断层扫描（PET）来评估与简单重复运动、不同长度的熟练序列手指运动以及自选运动相关的局部脑血流（rCBF）。帕金森病患者的序列手指运动与在正常受试者中发现的激活模式相似，但帕金森病患者在前楔叶、运动前区和顶叶皮质表现出相对过度活动。运动复杂性的增加导致正常受试者运动前区和顶叶皮质的rCBF增加；帕金森病患者在这些相同区域有更大幅度的增加，并且在前辅助运动区（SMA）/扣带回有额外的显著增加。正常受试者进行自选运动可诱导前SMA/扣带回的显著激活，但帕金森病患者则无此现象。我们得出结论，帕金森病患者需要募集更多的皮质区域来进行序列手指运动；这可能是皮质 - 皮质活动增加以代偿纹状体功能障碍的结果。
To study the difficulty that patients with Parkinson's disease have in performing long sequential movements, we used (H2O)-O-15 PET to assess the regional cerebral blood flow (rCBF) associated with the performance of simple repetitive movements, well-learned sequential finger movements of varying length and self-selected movements. Sequential finger movements in the Parkinson's disease patients were associated with an activation pattern similar to that found in normal subjects, but Parkinson's disease patients showed relative overactivity in the precuneus, premotor and parietal cortices, Increasing the complexity of movements resulted in increased rCBF in the premotor and parietal cortices of normal subjects; the Parkinson's disease patients showed greater increases in these same regions and had additional significant increases in the anterior supplementary motor area (SMA)/cingulate. Performance of self-selected movements induced significant activation of the anterior SMA/cingulate in normal subjects but not in Parkinson's disease patients. We conclude that in Parkinson's disease patients more cortical areas are recruited to perform sequential finger movements; this may be the result of increasing corticocortical activity to compensate for striatal dysfunction.