The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma
The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma
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DOI：
10.1111/j.1365-2559.2011.03764.x
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发表时间：
2011-02-01
期刊：
影响因子：
6.4
通讯作者：
Naito, Makoto
中科院分区：
文献类型：
--
作者：
Kunii, Ryosuke;Jiang, Shuying;Naito, Makoto
目的：探讨TTF-1阴性肺腺癌组织中粘蛋白的产生和肝细胞核因子4 α（hepatocyte nuclear factor-4 alpha，HNF 4 α）的表达情况。材料与方法：对262例肺腺癌进行组织学和免疫组化检查，222例（84.7%）TTF-1阳性，40例（15.3%）TTF-1阴性。在TTF-1阴性病例中，有31例粘液型肿瘤，HNF 4 α、MUC 5AC和MUC 2分别在34例（85%）、29例（72.5%）和4例（10%）中表达。相反，它们的表达在TTF-1阳性肿瘤中很少见。结论：TTF-1阴性肺腺癌多为黏液性病变，HNF 4 α和MUC 5AC的表达占优势。
Aims:To investigate TTF-1-negative pulmonary adenocarcinoma, focusing upon mucin production and the expression of hepatocyte nuclear factor-4 alpha (HNF4 alpha).Materials and methods:Two hundred and sixty-two cases of pulmonary adenocarcinoma were examined histologically and immunohistochemically; TTF-1 was expressed in 222 cases (84.7%), and 40 cases (15.3%) were negative. Among TTF-1-negative cases there were 31 mucinous-type tumours, and HNF4 alpha, MUC5AC and MUC2 were expressed in 34 cases (85%), 29 cases (72.5%) and four cases (10%), respectively. In contrast, their expression was rare in TTF-1-positive tumours. A statistically inverse correlation was confirmed between the expression of TTF-1 and that of HNF4 alpha and MUC5AC.Conclusion:Most TTF-1-negative pulmonary adenocarcinomas are mucinous lesions with the predominant expressionof HNF4 alpha and MUC5AC.