The third generation cohort of the national heart, lung, and blood institute's Framingham Heart Study: Design, recruitment, and initial examination
The third generation cohort of the national heart, lung, and blood institute's Framingham Heart Study: Design, recruitment, and initial examination
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DOI：
10.1093/aje/kwm021
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发表时间：
2007-06-01
影响因子：
5
通讯作者：
Levy, Daniel
中科院分区：
文献类型：
--
作者：
Splansky, Greta Lee;Corey, Diane;Levy, Daniel
近 60 年来，弗雷明汉心脏研究一直在研究心血管、肺部和其他疾病的自然史、危险因素和预后。原始队列的招募始于1948年。二十三年后，原始队列的3,548名子女及其配偶的1,576名加入了后代队列。从 2002 年开始，有 4,095 名在后代队列中至少有一位父母的成年人加入了第三代队列，另外还有 103 名第三代队列参与者的父母此前未加入后代队列。新招募的目的是补充从前几代获得的表型和基因型信息，并优先考虑较大的家庭。在 6,553 名符合资格的个人中，有 1,912 名男性和 2,183 名女性同意并参加了第一次检查（平均年龄：40（标准差：9）岁；范围：19-72 岁）。检查包括血管危险因素的临床和实验室评估以及亚临床动脉粥样硬化的影像学评估，以及心脏结构和功能的评估。将第三代队列数据与之前从前两代收集的测量数据进行比较，将有助于对亚临床和明显疾病的遗传和环境风险因素进行研究，重点是心血管和肺部疾病。
For nearly 60 years, the Framingham Heart Study has examined the natural history, risk factors, and prognosis of cardiovascular, lung, and other diseases. Recruitment of the Original Cohort began in 1948. Twenty-three years later, 3,548 children of the Original Cohort, along with 1,576 of their spouses, enrolled in the Offspring Cohort. Beginning in 2002, 4,095 adults having at least one parent in the Offspring Cohort enrolled in the Third Generation Cohort, along with 103 parents of Third Generation Cohort participants who were not previously enrolled in the Offspring Cohort. The objective of new recruitment was to complement phenotypic and genotypic information obtained from prior generations, with priority assigned to larger families. From a pool of 6,553 eligible individuals, 1,912 men and 2,183 women consented and attended the first examination (mean age: 40 (standard deviation: 9) years; range: 19-72 years). The examination included clinical and laboratory assessments of vascular risk factors and imaging for subclinical atherosclerosis, as well as assessment of cardiac structure and function. The comparison of Third Generation Cohort data with measures previously collected from the first two generations will facilitate investigations of genetic and environmental risk factors for subclinical and overt diseases, with a focus on cardiovascular and lung disorders.