HIGH-LEVEL TETRACYCLINE RESISTANCE IN NEISSERIA-GONORRHOEAE IS RESULT OF ACQUISITION OF STREPTOCOCCAL TETM DETERMINANT
HIGH-LEVEL TETRACYCLINE RESISTANCE IN NEISSERIA-GONORRHOEAE IS RESULT OF ACQUISITION OF STREPTOCOCCAL TETM DETERMINANT
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DOI：
10.1128/aac.30.5.664
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发表时间：
1986-11-01
影响因子：
4.9
通讯作者：
ROBERTS, MC
中科院分区：
文献类型：
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作者：
MORSE, SA;JOHNSON, SR;ROBERTS, MC
最近，已经分离出对四环素高度耐药的淋病奈瑟菌菌株（MIC为16至64 μ g/ml）。这种耐药性是由于获得了耐药性决定簇tetM，这是一种转座子携带的决定簇，最初发现于链球菌属，最近发现于人型支原体、解脲脲原体和阴道加德纳菌。在N. tetM决定簇位于一个25.2兆道尔顿的质粒上。该质粒由tetM插入到24.5兆道尔顿淋球菌接合质粒中产生。tetM决定簇可以转移到合适的受体菌株中。淋病通过遗传转化和接合。
Recently, strains of Neisseria gonorrhoeae have been isolated which are highly resistant to tetracycline (MICs of 16 to 64 .mu.g/ml). This resistance was due to the acquisition of the resistance determinant tetM, a transposon-borne determinant initially found in the genus Streptococcus and more recently in Mycoplasma hominis, Ureaplasma urealyticum, and Gardnerella vaginalis. In N. gonorrhoeae, the tetM determinant was located on a 25.2-megadalton plasmid. This plasmid arose from the insertion of tetM into the 24.5-megadalton gonococcal conjugative plasmid. The tetM determinant could be transferred to suitable recipient strains of N. gonorrhoeae by both genetic transformation and conjugation.