IMMUNITY TO INFECTION WITH SALMONELLA-TYPHIMURIUM - MOUSE-STRAIN DIFFERENCES IN VACCINE-MEDIATED AND SERUM-MEDIATED PROTECTION
IMMUNITY TO INFECTION WITH SALMONELLA-TYPHIMURIUM - MOUSE-STRAIN DIFFERENCES IN VACCINE-MEDIATED AND SERUM-MEDIATED PROTECTION
复制标题
DOI：
10.1093/infdis/150.3.425
复制
发表时间：
1984-01-01
影响因子：
6.4
通讯作者：
SULTZER, BM
中科院分区：
文献类型：
--
作者：
EISENSTEIN, TK;KILLAR, LM;SULTZER, BM
检测了C3 H谱系中的三个小鼠品系C3 H/HeJ、C3 HeB/FeJ和C3 H/HeNCr 1BR对S.通过一组无活力的疫苗和通过超免疫血清的被动转移来感染鼠伤寒沙门氏菌。这些菌株对S.鼠伤寒沙门氏菌，但都是组织相容性的。同样的疫苗对不同的小鼠品系表现出了截然不同的保护能力。保护能力与小鼠对特定疫苗产生凝集或抗O抗体（如ELISA [酶联免疫吸附试验]所示）的能力没有密切关系。抗体的被动转移保护了固有抗性小鼠，但不保护固有易感品系。这些观察结果表明，实验室之间报告的疫苗有效性差异可能归因于所用小鼠品系的差异，并提出了一个问题，即人类沙门氏菌感染的适当小鼠模型可能是什么。
Three mouse strains in the C3H lineage, C3H/HeJ, C3HeB/FeJ and C3H/HeNCr1BR, were tested for their ability to be protected against infection with S. typhimurium by a panel of nonviable vaccines and by passive transfer of hyperimmune serum. These strains differ in their innate susceptibilities to infection with S. typhimurium, but all are histocompatible. The same vaccines showed a widely different ability to protect different mouse strains. Ability to protect was not closely related to the capacity of the mice to make either agglutinating or anti-O antibody (as shown by ELISA [enzyme-linked immunosorbent assay]) in response to a particular vaccine. Passive transfer of antibody protected inherently resistant mice but not inherently susceptible strains. These observations suggest that reported discrepancies in vaccine efficacy among laboratories may be attributable to differences in the mouse strains used and raise the question as to what might be an appropriate mouse model for human infections with Salmonella spp.