Evidence for Innate Immune System Activation in HIV Type 1-Infected Elite Controllers
Evidence for Innate Immune System Activation in HIV Type 1-Infected Elite Controllers
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DOI：
10.1093/infdis/jit581
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发表时间：
2014-03-15
影响因子：
6.4
通讯作者：
Sereti, Irini
中科院分区：
文献类型：
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作者：
Krishnan, Sonya;Wilson, Eleanor M. P.;Sereti, Irini
背景资料。精英控制器在没有抗逆转录病毒治疗(ART)的情况下保持高的CD4(+)T细胞计数，并抑制血浆人类免疫缺陷病毒(HIV)病毒血症。目前尚不清楚与凝血、单核细胞激活和炎症相关的生物标记物水平是否在精英控制员、患有抑制性病毒血症的ART接受者中存在差异(血浆HIV1RNA负荷，
Background. Elite controllers maintain high CD4(+) T-cell counts and suppress plasma human immunodeficiency virus (HIV) viremia in the absence of antiretroviral therapy (ART). It is unclear whether levels of biomarkers associated with coagulation, monocyte activation, and inflammation, which are linked to HIV-associated mortality, differ among elite controllers, ART recipients with suppressed viremia (plasma HIV type 1 RNA load,