The effects of norepinephrine depletion on cerebral blood flow in the rat.
The effects of norepinephrine depletion on cerebral blood flow in the rat.
复制标题
去甲肾上腺素耗竭对大鼠脑血流量的影响。
DOI：
10.1016/0006-8993(89)91431-5
复制
发表时间：
1989
期刊：
影响因子：
2.9
通讯作者：
Solomon,RA
中科院分区：
文献类型：
--
作者：
Onesti,ST;Strauss,RC;Mayol,B;Solomon,RA
通过脑室内注射 6-羟基多巴胺 (6-OHDA) 的 10 只大鼠和 8 只注射生理盐水的对照大鼠，通过 [14C] 丁醇指示剂分级测量脑血流量 (CBF)。用 6-OHDA 治疗的大鼠皮质去甲肾上腺素 (NE) 水平降低了 83%。与对照组相比，6-OHDA治疗组大鼠CBF显着增加（平均全脑血流量分别为126.0±8.3和97.1±10.6ml·min−1·10−2g−1，P<0.05）。这些研究表明，大脑和脑微血管的去甲肾上腺素能神经支配对静息 CBF 具有调节作用。
Cerebral blood flow (CBF) was measured by [14C]butanol indicator fractionation in 10 rats given intraventricular injections of 6-hydroxydopamine (6-OHDA) compared to 8 saline-injected controls. Rats treated with 6-OHDA displayed an 83% reduction in cortical norepinephrine (NE) levels. CBF was significantly increased in 6-OHDA-treated rats compared to controls (average whole brain blood flow of 126.0 ± 8.3 and 97.1 ± 10.6 ml·min−1·10−2g−1respectively,P<0.05). These studies suggest that noradrenergic innervation of the brain and cerebral microvasculature exerts a moderating effect on resting CBF.