Fibroblasts and myofibroblasts in wound healing.
Fibroblasts and myofibroblasts in wound healing.
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DOI：
10.2147/ccid.s50046
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Desmoulière A
中科院分区：
文献类型：
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作者：
Darby IA;Laverdet B;Bonté F;Desmoulière A
（Myo）成纤维细胞是维持皮肤稳态和协调生理组织修复的关键角色。（Myo）成纤维细胞嵌入其分泌的复杂的细胞外基质（ECM）中，并且（Myo）成纤维细胞与其微环境之间存在复杂的互动对话。除了分泌ECM外，（肌）成纤维细胞通过分泌基质金属蛋白酶和金属蛋白酶的组织抑制剂，能够重塑这种ECM。（Myo）成纤维细胞及其微环境在组织修复过程中形成了一个不断进化的网络，相互作用导致细胞分化、增殖、静止或凋亡，并通过结合、隔离和激活对生长因子的生物利用度起作用。此外，（肌）成纤维细胞表型受机械应力的调节，因此受机械信号的调节。在病理情况下（过度疤痕或纤维化），或在衰老过程中，（肌）成纤维细胞与其微环境之间的这种对话可能被改变或破坏，导致修复缺陷或损伤，受损和/或美容皮肤改变，如皱纹的发展。因此，肌成纤维细胞与其微环境之间的亲密对话代表了一个迷人的领域，必须更好地理解，以便不仅表征能够预防或治疗病理发展的新治疗靶点和药物，而且还能干扰在有害环境引起的正常衰老或过早衰老过程中观察到的皮肤变化。
(Myo)fibroblasts are key players for maintaining skin homeostasis and for orchestrating physiological tissue repair. (Myo)fibroblasts are embedded in a sophisticated extracellular matrix (ECM) that they secrete, and a complex and interactive dialogue exists between (myo)fibroblasts and their microenvironment. In addition to the secretion of the ECM, (myo)fibroblasts, by secreting matrix metalloproteinases and tissue inhibitors of metalloproteinases, are able to remodel this ECM. (Myo)fibroblasts and their microenvironment form an evolving network during tissue repair, with reciprocal actions leading to cell differentiation, proliferation, quiescence, or apoptosis, and actions on growth factor bioavailability by binding, sequestration, and activation. In addition, the (myo)fibroblast phenotype is regulated by mechanical stresses to which they are subjected and thus by mechanical signaling. In pathological situations (excessive scarring or fibrosis), or during aging, this dialogue between the (myo)fibroblasts and their microenvironment may be altered or disrupted, leading to repair defects or to injuries with damaged and/or cosmetic skin alterations such as wrinkle development. The intimate dialogue between the (myo)fibroblasts and their microenvironment therefore represents a fascinating domain that must be better understood in order not only to characterize new therapeutic targets and drugs able to prevent or treat pathological developments but also to interfere with skin alterations observed during normal aging or premature aging induced by a deleterious environment.