Lifestyle risk factors for lower limb venous reflux in the general population: Edinburgh Vein Study
Lifestyle risk factors for lower limb venous reflux in the general population: Edinburgh Vein Study
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DOI：
10.1093/ije/30.4.846
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发表时间：
2001-08-01
影响因子：
7.7
通讯作者：
Ruckley, CV
中科院分区：
文献类型：
--
作者：
Fowkes, FGR;Lee, AJ;Ruckley, CV
背景静脉曲张在普通人群中很常见，但病因学尚未完全确定。静脉曲张常与瓣膜功能不全引起的腿部静脉血液回流有关。我们的目的是确定在一般人群中的生活方式因素与反流，从而牵连在病因学的静脉曲张veines.Methods在爱丁堡静脉研究，1566名男性和女性年龄在18-64岁，随机抽样的一般人群在城市的爱丁堡，苏格兰，并进行了双重扫描，以衡量在每条腿的8个静脉段反流。一份自填式问卷询问了职业、工作时的流动性、吸烟、产科史、膳食纤维摄入量和排便习惯。结果在女性中，静脉回流与工作时坐着的减少有关（比值比[OR] = 0.76，95% CI：0.61-0.94），既往妊娠（OR = 1.20，95% CI：0.93-1.54），口服避孕药使用率较低（OR = 0.84，95% CI：0.66-1.06）。浅表反流女性的平均体重指数高于无反流女性：26.2 kg/m2（95% CI：25.5-27.0）vs 25.2 kg/m2（95% CI：24.8-25.6）。在年龄调整后，坐着工作仍然与反流（OR = 0.78，95%CI：0.63-0.98）和既往使用口服避孕药与浅表反流（OR = 0.71，95%CI：0.50-1.01）相关。在男性年龄校正分析中，身高与反流相关（OR = 1.13，95% CI：1.02-1.26），大便紧张与浅表反流相关（OR = 1.94，95% CI：1.12-3.35）。在任何性别之间的反流和社会阶层，终身吸烟，膳食纤维摄入量和肠道通过time.Conclusions没有发现任何关联，这项人口研究没有确定强大的和一致的生活方式的风险因素静脉反流，虽然以前怀孕，口服避孕药的使用率较低，肥胖和流动性在工作中的妇女和身高和紧张的男性大便可能有牵连。
Background Varicose veins occur commonly in the general population but the aetiology is not well established. Varicosities are associated frequently with reflux of blood in the leg veins due to valvular incompetence. Our aim was to determine in the general population which lifestyle factors were related to reflux and thus implicated in the aetiology of varicose veins.Methods In the Edinburgh Vein Study, 1566 men and women aged 18-64 years were sampled randomly from the general population in the city of Edinburgh, Scotland, and had duplex scans to measure reflux in eight venous segments in each leg. A self-administered questionnaire enquired about occupation, mobility at work, smoking, obstetric history, dietary fibre intake and bowel habit. A bowel record form was completed subsequently.Results In women, venous reflux was associated with decreased sitting at work (odds ratio [OR] = 0.76, 95% CI: 0.61-0.94), previous pregnancy (OR = 1.20, 95% CI : 0.93-1.54), and a lower prior use of oral contraceptives (OR = 0.84, 95% CI: 0.66-1.06). Mean body mass index was greater in women with superficial reflux compared to those with no reflux: 26.2 kg/m(2) (95% CI : 25.5-27.0) versus 25.2 kg/m(2) (95% CI: 24.8-25.6). On age adjustment, sitting at work remained related to reflux (OR = 0.78, 95% CI : 0.63-0.98) and prior use of oral contraceptives to superficial reflux (OR = 0.71, 95% CI: 0.50-1.01). In age-adjusted analyses in men, height was related to reflux, (OR = 1.13, 95% CI: 1.02-1.26) and straining at stool was related to superficial reflux (OR = 1.94, 95% CI: 1.12-3.35). No associations were found in either sex between reflux and social class, lifetime cigarette consumption, dietary fibre intake and intestinal transit time.Conclusions This population study did not identify strong and consistent lifestyle risk factors for venous reflux although previous pregnancy, lower use of oral contraceptives, obesity and mobility at work in women and height and straining at stool in men may be implicated.