[Liver cancer epidemiology in China, 2015].
[Liver cancer epidemiology in China, 2015].
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DOI：
10.3760/cma.j.issn.0253-3766.2019.10.001
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发表时间：
2019-10-23
期刊：
影响因子：
--
通讯作者：
He, J
中科院分区：
文献类型：
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作者：
An, L;Zeng, H M;He, J
目的：利用最新的基于人群的癌症登记（PBCR）数据，我们估计了中国全国范围内按性别和地区划分的肝癌统计数据。方法：将2015年符合数据质量标准的肝癌PBCR数据按地理位置、性别、年龄组进行分层。按性别和地区计算特定年龄的发病率和死亡率。肝癌的负担是通过将这些比率乘以2015年的人口来评估的。采用2000年中国标准人口和世界Segi人口计算发病率和死亡率的年龄标准化率。结果：全国有368个癌症登记机构，覆盖人口3090553499人，占全国人口的22.52%。据估计，中国有37万肝癌新发病例（男性27.4万例，女性9.6万例）。中国标准人群（ASR China）和世界Segi人群（ASR World）年龄标准化发病率分别为17.64 / 10万和17.35 / 10万。农村地区的发病率（中国：20.07 / 10万，世界：19.67 / 10万）高于城市地区（中国：15.90 / 10万，世界：15.67 / 10万）。亚组分析显示，中国西部地区肝癌发病率最高，中国ASR为20.65 / 10万，世界ASR为20.22 / 10万。在新发肝癌死亡病例中，中国有32.6万例新发死亡病例（男性24.2万例，女性8.4万例），按中国标准人口和世界Segi人口计算的年龄标准化死亡率分别为15.33 / 10万和15.09 / 10万。农村死亡率（中国ASR: 17.17 / 10万，世界ASR: 16.86 / 10万）高于城市（中国ASR: 14.00 / 10万，世界ASR: 13.81 / 10万）。结论：中国的肝癌患者负担仍很重。农村居民肝癌的发病率和死亡率都高于城市居民。可能是肝炎病毒感染、黄曲霉毒素暴露等多种因素起主导作用。今后应加强防控战略。
Objective: Using updated population-based cancer registration (PBCR) data, we estimated nation-wide liver cancer statistics overall, by sex and by areas in China. Methods: Qualified PBCR data of liver cancer in 2015 which met the data quality criteria were stratified by geographical locations, sex, and age groups. Age-specific incidence and mortality rates by sex and area were calculated. The burden of liver cancer was evaluated by multiplying these rates by the year of 2015 population. Chinese standard population in 2000 and World Segi's population were used for the calculation of age-standardized rates (ASR) of incidence and mortality. Results: Qualified 368 cancer registries covered a total of 309 553 499 populations in China, accounting for 22.52% of the national population. It is estimated that there were 370 000 new cases (274 000 males and 96 000 females) of liver cancer in China. The age-standardized incidence rates by Chinese standard population (ASR China) and World Segi's population (ASR World) were 17.64 per 100 000 and 17.35 per 100 000, respectively. Rural areas showed higher incidence (ASR China: 20.07 per 100 000, ASR World: 19.67 per 100 000) than urban areas (ASR China: 15.90 per 100 000, ASR world: 15.67 per 100 000). Subgroup analysis showed that western areas of China had highest incidence rate of liver cancer, with the ASR China of 20.65 per 100 000 and 20.22 per 100 000 for ASR world, respectively. For new cases of liver cancer deaths, there were 326 000 new deaths (242 000 males and 84 000 females) in China, with age-standardized mortality rate by Chinese standard population and World Segi's population of 15.33 per 100 000 and 15.09 per 100 000, respectively. Rural areas showed higher mortality (ASR China: 17.17 per 100 000, ASR world: 16.86 per 100 000) than urban areas (ASR China: 14.00 per 100 000, ASR World: 13.81 per 100 000). Conclusions: There is still a heavy burden of liver cancer in China. Rural residents have higher incidence and mortality of liver cancer compared with urban counterparts. It is likely that many factors such as hepatitis virus infection, and aflatoxin exposure play a dominating role. Prevention and control strategies should be enhanced in the future.